Magnetic Resonance Imaging (MRI) has excellent soft-tissue contrast, multi-planar imaging capability, and sensitivity to subtle changes in tissue morphology and function Ultrasound imaging, on the other hand, has high temporal resolution volumetric imaging capabilities, the ability to quantify of blood flow, and detect boundaries with small acoustic impedance differences. In addition ultrasound...

We describe the case of a 76-year-old man with a history of ischemic heart disease and functional mitral regurgitation who over the previous six months had experienced worsening of functional class (NYHA III/IV) under optimal medical therapy, without ischemic symptoms and with negative ischemic tests. Mitral valve annuloplasty was considered. As the patient presented left bundle branch block on...

Diffusion-weighted imaging (DWI) offers insight into cellular status, density, and structural organization by way of sequences sensitive to water mobility which is affected by these properties [1, 2]. Macroscopic tissue motion unrelated to diffusion can confound in vivo diffusion measurements therefore single-shot techniques are nearly exclusively used to mitigate extraneous motion, particularl...

Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...

BACKGROUND Established methods to determine asynchrony suffer from high intra- and interobserver variability and failed to improve patient selection for cardiac resynchronization therapy (CRT). Thus, there is a need for easy and robust approaches to reliably assess cardiac asynchrony. METHODS AND RESULTS We performed echocardiography in 100 healthy subjects and 33 patients with left bundle br...

Near-infrared spectroscopy and imaging are powerful tools to detect and continuously monitor the cerebral hemodynamic and oxygenation changes induced by brain activity. However, in addition to the focal neuronal-activation-induced hemodynamic signals, near-infrared methods are also sensitive to the cerebral hemodynamic fluctuations of systemic origin associated, for instance, with the arterial ...

as a nuclear approach, positron emission tomography (pet) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. there are certain limitations to this technique such as normal tissue uptake. therefore, it has been recommended that patients prepare before scanning. fasting for a short while before pet imaging is an exampl...

To study the functional role of synchronized neuronal activity in the human motor system, we simultaneously recorded cortical activity by high-resolution electroencephalography (EEG) and electromyographic (EMG) activity of the activated muscle during a phasic voluntary movement in seven healthy subjects. Here, we present evidence for dynamic beta-range (16-28 Hz) synchronization between cortica...

Description of the technology The detection of structural and functional proteins in cells within the tumor microenvironment in tissue samples is achieved by immunolabeling with specific antibodies. These target proteins are visualized with the subsequent application of either an enzymatic reaction that induces chromogen precipitation at the site of antibody-antigen binding (immunoenzyme method...