AIMS To study the distribution of longitudinal systolic strain and strain rate (SR) as indicators of myocardial deformation according to age and sex in a healthy population. METHODS AND RESULTS Longitudinal strain and SR were determined in 1266 healthy individuals from three standard apical views, using a combination of speckle tracking (ST) and tissue Doppler imaging (TDI) to track regions o...

BACKGROUND Childhood cancer survivors treated with anthracyclines and mediastinal irradiation are at risk for late onset cardiotoxicity. AIMS OF THE STUDY To assess the role of N-terminal pro-brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) as early predictors of late onset cardiotoxicity in asymptomatic survivors of childhood cancer treated with doxorubicin with or with...

BACKGROUND Subclinical left (LV) and right ventricular (RV) dysfunction has been demonstrated in type 2 diabetes mellitus and evidence indicates impaired LV diastolic function in type 1 diabetes mellitus (T1DM) as well. The aim of our study was to evaluate the role of tissue Doppler imaging (TDI) in assessment of global LV and RV function in T1DM patients. METHODS A detailed two-dimensional, ...

The aim of the present study was to assess the ability of several echocardiographic and TDI (tissue Doppler imaging) parameters to predict an elevated LVEDP (left ventricular end-diastolic pressure) in patients with abnormal relaxation. Eighty-two consecutive patients presenting with an E /A ratio (ratio of early-to-late diastolic peak transmitral velocity) <0.9 scheduled for left heart cathete...

BACKGROUND Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissu...

OBJECTIVE To determine the association between left ventricular (LV) dyssynchrony assessed by tissue Doppler imaging (TDI) in patients with left ventricular ejection fraction (LVEF) < 35% and prolonged ventricular depolarization on electrocardiography. STUDY DESIGN A cross-sectional study. PLACE AND DURATION OF STUDY The Aga Khan University, Karachi, from June to September 2007. METHODOLO...

BACKGROUND Myocardial iron overload is the most common cause of mortality in patients with thalassemia major (TM), also known as beta-thalassemia. T2* cardiovascular magnetic resonance imaging (MRI) is the best way of monitoring cardiac iron, and new echocardiographic techniques can be used to assess cardiac function. OBJECTIVES The aim of this study was to assess the systolic and diastolic r...

Background PVM is capable of accurately and reproducibly measuring myocardial velocities in the LV [1]. However, analyzing RV motion is more difficult because of the thinness of the free wall and its asymmetrical geometry. Currently, the most commonly used technique for assessing RV velocities and function is Tissue Doppler Imaging (TDI) where the high temporal resolution allows the detailed an...

BACKGROUND Right ventricular (RV) dysfunction complicates advanced left ventricular (LV) heart failure (HF) and contributes to a poor prognosis. Levosimendan is a positive inotropic agent improving cardiac contractility without increasing myocardial oxygen consumption in HF. AIM To evaluate the effect of levosimendan therapy on RV systolic function, by using derived tissue Doppler imaging (TD...

The propagation velocity of shear waves relates to tissue stiffness. We prove that a regular clinical cardiac ultrasound system can determine shear wave velocity with a conventional unmodified tissue Doppler imaging (TDI) application. The investigation was performed on five tissue phantoms with different stiffness using a research platform capable of inducing and tracking shear waves and a clin...