Submitted 2011.09.28. Accepted for publication 2011.12.19. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegra...

Amlodipine besylate is a long‐acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and the rate of absorption is often controlled by the rate of dissolution. The rate of dissolution will increase by incorporating the drug in a fast dissolving dosage form. An attempt will be made to dev...

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it sh...

Deparaffinization is one of the stages tissue processing, which aims to dissolve paraffin for full-color application. can only be done by xylol as fat. Liquid laundry detergent has main component in form a surfactant property removing types lipids dissolving and emulsification because carcinogenic properties, flammable relatively expensive. This study aimed describe quality preparations using l...

Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the dissolving MNs release the loaded vaccine antigen into the skin. To shorten skin application time for ...

Ondansetron is a highly selective serotonin (5-HT3) receptor blocker which inhibits serotonin to bind with serotonin 5-HT3 receptors and hence prevent the vomiting reflex induced by serotonin. This work aimed to develop rapid dissolving films of ondansetron for the treatment of chemotherapy induced nausea and vomiting. Rapid dissolving films were prepared by solvent casting method using pullula...

We investigate the dissolution of artificial fractures with three-dimensional, pore-scale numerical simulations. The fluid velocity in the fracture space was determined from a lattice-Boltzmann method, and a stochastic solver was used for the transport of dissolved species. Numerical simulations were used to study conditions under which long conduits (wormholes) form in an initially rough but s...

Automated knowledge management techniques critically depend on the availability of semantically enhanced documents which are hard to come by in practice. Starting from a detailed look at the motivations of users to produce semantic data, we argue that the authoring problem experienced by MKM is actually an author’s dilemma. An analysis of the content authoring process suggests that the dilemma ...

Corn stalk can be used as an alternative non-wood raw material to produce cellulosic dissolving grade pulp. In this work, the potential of corn stalk in the production of dissolving pulp (alpha-cellulose) was investigated. It was collect ed from a corn stalk farm of Kermanshah, Iran. The sequences of experimental work were: water and acid prehydrolysis at 160˚C for 30min, followed by Kraft pulp...

Cu electropolishing was studied using a rotating disc electrode in a variety of phosphoric acid-based electrolytes, including several with ethanol and other species added as diluents. Diluents allow a wider range of water concentrations and electrolyte viscosities to be accessed and also reduce the removal rate during Cu electropolishing, simplifying possible application to damascene processing...