Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF-β signal transductio...

Relatively few studies have been made of the influence of the thyroid gland on the development and growth of tumors. Lerman (15) stated that the thyroid does not greatly influence the onset and growth of either experimental or human cancer, but Rawson (17) recently cited some experimental and clinical observations which suggest that hyperthyroidism may inhibit, while hypothyroidism may enhance,...

Metastases of differentiated thyroid cancer (DTC) can lose affinity to radioiodine with the passage of time, with resultant difficulty in management. Thyroid tumors are known to express somatostatin receptors and therefore 111In-pentetreotide, somatostatin analogue, can visualize tumors with high concentration of somatostatin receptors. We report a case of I-131 whole body scan (WBS) negative r...

BACKGROUND Papillary thyroid carcinoma (PTC) is often accompanied by lymph node metastasis (LNM), compared with follicular thyroid carcinoma (FTC). Sialic acid is carried by fibronectin (sFN) as the antigen of monoclonal antibody (MoAb) JT-95 detected in 90% of PTC, and a few cases of FTC. PATIENTS AND METHODS JT-95 staining was performed in 9 PTC and 20 follicular type tumors to investigate ...

Familial follicular cell-derived well-differentiated thyroid cancer, papillary (PTC), and follicular thyroid carcinomas (FTC), accounts for 95% of thyroid malignancies. The majority of are sporadic, and at least 5% of these patients will have familial disease. Familial thyroid syndromes are classified into familial medullary thyroid carcinoma (FMTC), derived from calcitonin-producing C cells, a...

Every year, 18,000 new thyroid cancer cases are reported in the United States, representing 1.2% of the total number of new cancer cases of all sites. Thyroid cancer accounts for 1,200 deaths, or 0.2% of the total number of deaths related to cancer.1 Over the last two decades, there has been important progress in our understanding of tumors of the thyroid gland, from both histopathologic and et...

F-18 FDG is the most widely used tracer in molecular imaging and it is applied for many purposes mainly in malignant diseases. Incidental finding are common in FDG-PET/CT imaging and includes benign and malignant lesions. Among the rare tumors , adrenal oncocytomas are uncommon findings and incidental findings of thyroid malignancies are not rare. Oncocytoma is a rare adrenocortical tumor and m...

Papillary thyroid carcinoma (PTC) is clinically heterogeneous. Apart from an association with ionizing radiation, the etiology and molecular biology of PTC is poorly understood. We used oligo-based DNA arrays to study the expression profiles of eight matched pairs of normal thyroid and PTC tissues. Additional PTC tumors and other tissues were studied by reverse transcriptase-PCR and immunohisto...

CONTEXT A better means to accurately identify malignant thyroid nodules and to distinguish them from benign tumors is needed. We previously identified markers for detecting thyroid malignancy, with sensitivity estimated at or close to 100%. One lingering problem with these markers was that false positives occurred with Hürthle cell adenomas (HCA) which lowered test specificity. METHODS To loc...

The transformation of endodermal-derived thyroid follicular cells or neural crest– derived thyroid C cells leads to distinct types of cancer (Fig. 1). Follicular cells give rise to two main forms of differentiated thyroid cancer: papillary thyroid carcinoma and follicular thyroid carcinoma. Poorly differentiated and anaplastic thyroid carcinomas are comparatively rare tumors that also arise fro...