Objectives: Interferon-alpha (IFN-α) is increasingly being used in the treatment of the Philadelphia-negative chronic myeloproliferative neoplasms (MPNs). However, some 20% of patients discontinue treatment because of side effects, including thyroid dysfunction. Methods: This retrospective study reports patients with MPNs who developed autoimmune thyroid disease (AITD) during treatment with IFN...

INTRODUCTION Hepatitis delta virus (HDV) infection is a serious health problem worldwide. Thyroid disturbances represent a major limitation to the efficacy of interferon treatment targeting chronic HDV (C-HDV) infection. Moreover, pre-treatment thyroid diseases may be influenced by interferon therapy. Despite this, the characteristic features of the thyroid diseases in C-HDV patients remain poo...

BACKGROUND Levothyroxine (L-T4) treatment of euthyroid children with Hashimoto thyroiditis (HT) is a controversial issue. PATIENTS AND METHODS We conducted a prospective, randomized, controlled clinical trial. Out of 79 identified euthyroid patients, 59 started the study; 25 patients (21 female, 4 male; age: 11.8 ± 2.3 years) received L-T4 at a mean dose of 1.6 µg/kg (SD, 0.8) daily, and 34 (...

BACKGROUND Thyroid disorders may affect all of the organ systems of the body and they are also highly associated with a wide variety of skin disorders. The aim of this study was to investigate the prevalence of thyroid function abnormalities and thyroid autoimmunity in patients with pemphigus vulgaris (PV) and to determine the association between thyroid disorders and clinical involvement and s...

Background: Evaluation of thyroid disorder in pregnancy is essential for maternal health, obstetrical outcome and neurodevelopment the child. Euthyroid pregnant women having positive peroxidase antibodies have an elevated risk miscarriage, premature birth, gestational hypertension, intrauterine fetal demise. Thyroid autoimmunity (TAI) subclinical hypothyroidism (SCH) been connected with adverse...