OBJECTIVE Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of thi...

Thyroid surgeons are becoming increasingly more aware of a histologically distinct subset of thyroid carcinoma whose classification falls between well-differentiated and anaplastic carcinomas with respect to both cell differentiation and clinical behavior. This subtype of tumors has been categorized as poorly differentiated or insular carcinoma, based on its characteristic cell groupings. Altho...

♦Corresponding Author: Negar Azarpira, MD Organ Transplant Research Center, Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran Tel: +98-711-647 4331 Email: [email protected] Introduction The presence of synchronous malignant tumors in patients with squamous cell carcinoma (SCC) of the pharynx is not a rare event. This is important because it can decrease the overall su...

Introduction: Although co-occurring thyroid pathologies are common in patients with primary hyperparathyroidism, synchronous parathyroid and differentiated thyroid carcinoma is a rare situation. Case: A 65-year-old woman presented to our endocrinology clinic for evaluation of hypercalcemia. She had an albumin-corrected serum calcium (Ca) concentration of 12.4 mg/dl (normal, 8.6-10 mg/dl), serum...

introduction:  in order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (dtc), after l-t4 withdrawal (short-term overt hypothyroidism) and during tsh suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. methods: 24 patients with dtc were studied in two phases: 1: at least 4 weeks after l-t4 withdr...

type of midline neck masses in children. Though usually benign, 1% of cysts may undergo neoplastic change. The most common histological subtype is papillary carcinoma (80%) followed in order of frequency by mixed follicular-papillary, squamous, follicular, anaplastic, and hurthle-cell carcinoma (1). The synchronous occurrence of thyroglossal duct carcinoma and thyroid carcinoma in the thyroid g...

The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 subjects with normal thyroid tissue. The positive rate of MUC1 detect...

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinog...

Laboratory procedures available for aid in the differential diagnosis of thyroid tumors include serum hormone measurements, a variety of thyroid scanning procedures, ultrasonography and needle biopsy of the thyroid. Serum calcitonin measurements appear to be highly reliable indicators of the pres­ ence of medullary carcinoma of the thyroid gland. Thyroid scans using isotopes of iodide or techne...

Surgical strategy for patients with papillary thyroid carcinoma invading the trachea: a comparison of tracheal sleeve resection end-to-end anastomosis and window tracheocutaneous fistula