Telomerase activity is known to be absent from most normal and well-differentiated tissues, although being detectable in the vast majority of malignant tumors. An increasing number of reports demonstrate that telomerase may be activated in benign tumors, such as adenomas. We have investigated a series of normal and neoplastic thyroid tissues for the presence of telomerase activity. As expected,...

Thyroid hormone is a major regulator of thermogenesis, acting both in peripheral organs and on central autonomic pathways. Mice heterozygous for a point mutation in thyroid hormone receptor α1 display increased thermogenesis as a consequence of high sympathetic brown fat stimulation. Surprisingly, despite the hypermetabolism, their body temperature is not elevated. Here we show, using isolated ...

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

Background: The thyroid gland absorbs nearly all the iodine in the blood, independently of its isotopic composition. When a large enough activity of radioactive iodine like 131I, 132I, 133I is taken into the body, it can destroy the healthy thyroid gland cells as well as the cancer’s cells. In fact, as it is well known, some isotopes of iodine are used not only for acquiring thyroid image...

Thyroid diseases are prevalent among endocrine disorders, and careful evaluation of patients' symptoms is a very important part in their diagnosis. Developing new pedagogical strategies, such as problem-based learning (PBL), is extremely important to stimulate and encourage medical and biomedical students to learn thyroid physiology and identify the signs and symptoms of thyroid dysfunction. Th...

INTRODUCTION Incidental hypermetabolic thyroid lesions on Positron Emission Tomography have significant clinical value and may harbor malignancy. In this study we evaluated laboratory, radiologic, and pathologic characteristics of incidental hypermetabolic thyroid lesions. MATERIALS AND METHODS We evaluated 18 patients prospectively with various malignancies and hypermetabolic thyroid inciden...

The influence of hypo- and hyper-thyroidism on spermatogenesis was studied in 60-day-old adult maleWistar rats. To confirm hypo- and hyper-thyroidism, the concentration of plasma thyroid hormones wereassayed by radioimmunoassay. The hypothyroid state, induced by administration of 25 mg/kg/daymethimazole for 5 successive days, resulted in significant decrease in the number of Sertoli cells, sper...

The increasing recognition of non-arteriosclerotic endomyocardial fibrosis as a significant cause of congestive cardiac failure in adults outside Africa as well as in Africa is noted. Five new cases occurring in Great Britain (one in an African) are added to the mounting literature on the subject. The main clinical and pathological features are summarized, and the suggestion is made that early ...

introduction: various radiopharmaceuticals, including 67ga, 201tl, and 99mtc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mtc-tetrofosmin, a lipophilic cationic radiotracer, and 99mtc-sestamibi have also been reported to accumulate in thyroid tumors. in this study, we evaluated the role of 99mtc-tetrofosmin in the differentiation of malignant from benign th...