OBJECTIVE Quinolone resistance is usually caused by various chromosomal mutations, but has been more recently associated with plasmids which carry the qnr determinant. The aim of this study is to investigate the prevalence of qnr genes in clinical isolates of Enterobacteriaceae in Jamaica. METHODS A total of 255 non-duplicate fluoroquinolone-resistant Enterobacteriaceae clinical isolates, com...

WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

AIM To evaluate the effect of thymoquinone on the healing of experimental left colon anastomosis in rats. METHODS Forty Wistar albino rats weighing 250-300 g were randomly divided into four groups (10 rats/group). Group 1 (control group) rats were not administered Thymoquinone (TQ) for 3 days after the operation. Group 2 was administered daily TQ for 3 days starting from the first day after t...

The traditional preparation process of Nigella sativa (NS) oil starts with roasting of the seeds, an allegedly unnecessary step that was never skipped. The aims of this study were to investigate the role and boundaries of thermal processing of NS seeds in the preparation of therapeutic extracts and to elucidate the underlying mechanism. NS extracts obtained by various seed thermal processing me...

Introduction: Nigella sativa, also known as black seed, cumin, and/or Habbatul Barakah, is a medicinal herbal plant. Thymoquinone (TQ), one of sativa's active ingredients, has been shown to be anticarcinogenic, anti-inflammatory, analgesic, and antimicrobial. Hydroxyapatite (HA) an inorganic mineral with the apatite lattice structure (A10(BO4)6C2). The aim current study incorporate thymoquinone...

objective: several phytochemical agents have been known to exhibit a neuroprotective effect. among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. this work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...

gastrointestinal (gi) diseases affect a large number of people all over the world. uncontrolled acid secretion and occurrence of gastric ulcers are common disorders of gi tract which pose serious problems to human health. many synthetic drugs have been used to treat gi disorders but a definite cure has not been discovered so far and the available medications cause several side effects. nigella ...

conclusions in conclusion, we suggest that tq may be used as a prophylactic agent against nephrotoxicity, especially in instances of tubular injury. however, human-based studies are still needed. objectives in this study, we investigated the comparative nephroprotective effects of silymarin, n-acetylcysteine (nac), and thymoquinone (tq) in animal models (rats) in which we induced nephrotoxicity...

Objective: The incidence and prevalence of kidney stone is increasing worldwide. After the first recurrence the risk of subsequent relapses is higher and the time period between relapses is shortened. Urinary stones can be severely painful and make a huge economic burden. The stone disease may increase the vulnerability of patients to other diseases such as renal failure. Medicinal herbs are ri...

Lead reproductive toxicity has been reported in men. Nigella sativa seed and its active component, thymoquinone have used traditional pharmacopeia as natural remedy to promote health. This study investigated the ameliorative potential of Thymoquinone (TQ) on male functions lead acetate (PbA)-induced Wistar rats. Thirty rats weighing 100–120 g were randomly divided into six groups (n=5); Control...