One of the most prominent features at the mid-blastula transition (MBT) observed in most embryos is a pause in cell cycle regulated by the nucleocytoplasmic (N/C) ratio. By using chromosome rearrangements to manipulate the DNA content of embryos, we determined that the threshold for this cell cycle pause in Drosophila is about 70% of the DNA content normally present at cycle 14. Embryos with DN...

Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline region and typically increases with increasing cycle number in the growth and...

A common gene regulatory network model is the threshold Boolean network, used for example to model the Arabidopsis thaliana floral morphogenesis network or the fission yeast cell cycle network. In this paper, we analyze a logical model of the mammalian cell cycle network and its threshold Boolean network equivalent. Firstly, the robustness of the network was explored with respect to update pert...

in this research, air sampling of workplaces was carried out by two methods (long - time and short - time). the mean formaldehyde concentration with long - time method in pathology labs, surgery and endoscopy sections were 0.96 0.25 and 0.13 ppm and with short - time method, 8 hours, was 3, 0.3 and 0.2 ppm. the mean formaldehyde concentration in pathology labs was above the standard values (tlv...

Aims. We investigate the statistical properties of the extreme events of the solar cycle as measured by the sunspot number. Methods. The recent advances in the methodology of the theory of extreme values is applied to the maximal extremes of the time series of sunspots. We focus on the extreme events that exceed a carefully chosen threshold and a generalized Pareto distribution is fitted to the...

In order to individualize the intensity of an aerobic training program on different ergometers in healthy elderly subjects using a single test of muscular exercise, we analysed cardiorespiratory responses in 8 men (65.7 +/- 4.5 yrs) and 10 women (63.3 +/- 4.8 yrs). The heart rate corresponding to the ventilatory threshold was defined as individualised exercise intensity. All subjects carried ou...

Introduction There is only limited information from previous studies that suggest that auditory function may be influenced by hormones. Recent advances in the field have exposed the potential role of hormones in modulating the auditory system. Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination. Methods Thi...

a b s t r a c t there are three types of nerve fibers that are involved in the transmission of pain stimuli: c fibers (slower fibers) for thermal, mechanical and chemical stimuli, a-delta fibers for thermal or mechanical stimuli and a-beta fibers for touch stimuli. clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...

Cell-cycle dysregulation is a hallmark of tumor cells and human cancers. Failure in the cell-cycle checkpoints leads to genomic instability and subsequent development of cancers from the initial affected cell. A worldwide used product Roundup 3plus, based on glyphosate as the active herbicide, was suggested to be of human health concern since it induced cell cycle dysfunction as judged from ana...