Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...

We report a case of 18-year-old female patient with large patent ductus arteriosus (PDA)-preductal coarctation of descending thoracic aorta. She underwent large PDA closure with a prosthetic graft from ascending aorta to descending thoracic aorta by mid-sternotomy on cardiopulmonary bypass machine under total hypothermic circulatory arrest.

angiotensin ii is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. since vascular reactivity to angiotensin ii changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

Computed tomography (СТ) with contrast enhancement allows a detailed anatomical description of feline thoracic aorta. For this purpose, 14 sexually mature clinically healthy domestic cats weighing 2.9 to 4.0 kg were investigated. The animals were anaesthetized and fixed in dorsal recumbency on a СТ table (Tomoscan, CX/Q, Siemens). Consequent transversal 5 mm cross-sections were made along the t...

Morphologic observations suggest that the inner layers of the thoracic aorta in man and dog are avascular and the outer layers have vasa vasorum. It appears that vasa vasorum are essential in the thoracic aorta because their interruption produces medial necrosis. These experiments provide the first measurements of blood flow through aortic vasa vasorum and examine physiologic regulation of that...