The aim of this experiment was to investigate whether the anorectic effect of apolipoprotein A-IV (apo A-IV) after lipid feeding is mediated via the central nervous system. Infusion of 0.5 micrograms of apo A-IV into the third ventricle failed to suppress food intake. Higher doses (1 micrograms or higher) of apo A-IV infused into the third ventricle inhibited food intake in a dose-dependent man...

49(638)-764], from the National Institutes of Health, United States Public Health Service (No. A2650) and from the Foundation for the study of Diabetes and Related Metabolic Disorders. The authors would like to express their gratitude to Dr Ned Redgate of the Dept. of Physiology for the performance of the operative procedure involving the infusion of [35S]cystine into the third ventricle of the...

Increased brain size has been observed in individuals with autism with a wide range of cognitive functioning. The purpose of this investigation was to obtain measurements of the brain volume in a sample of nonmentally retarded autistic individuals. Magnetic resonance imaging scans from 16 nonmentally retarded individuals with autism and 19 male volunteer comparison subjects were obtained and th...

The authors investigated the analgesic effects of small morphine doses injected into the paraventricular nucleus (PVN) of normal rats and hypophysectomized (Hx) rats. An injection cannula was stereotactically inserted into the PVN or third ventricle. On the 5-7th postoperative day, morphine (7 micrograms) was injected and the pain threshold (paw lick latency: PLL) was measured using a hot plate...

The objective was to study the relation between changes in cerebral ventricular size and clinical outcome after neuroendoscopic third ventriculostomy (NTV) in both primary (no previous surgery) and secondary (previous CSF diversion for hydrocephalus) NTV. Changes in ventricular size were related to the need for further surgery for CSF diversion. A blinded retrospective study of the pre-NTV and ...

The effects of intracerebroventricular application of melanin-concentrating hormone (MCH) on licking for sucrose, quinine hydrochloride (QHCl), and water solutions were evaluated in two experiments. In experiment 1, rats received 90-min access to sucrose and water solutions after MCH or vehicle microinjection to the third ventricle (3V). MCH increased intake largely through increases in the rat...

Chordoid gliomas are unusual tumors that are found in the anterior third ventricle and are slow growing. Till now approximately 55 cases of chordoid gliomas of the third ventricle are reported in world literature. Magnetic resonance imaging (MRI) studies show isointense in T1W and isoto hyperintense tumor in T2W with distinguished intense contrast enhancement and commonly hydrocephalus. These t...

The introduction of Shiga toxin into the ventricular system of the brain with major location in the third ventricle resulted in a response similar to that following the administration of the toxin either intravenously or by cross-circulation. The intravenous administration at the dosage level employed would have elicited no response. These observations lend support to the hypothesis that Shiga ...

Injections into third ventricle of brain of either 4 m Molar or 8 m Molar of GABA were given to intact and ovariectomized female rats to evaluate the effects of these dosages on body weight, food intake, water intake and blood glucose levels. Statistically significant reduction in food and water intake with 8 m Molar GABA was observed in intact female rats. Very precise alterations seen in ovar...

BACKGROUND Since the use of computed tomography and magnetic resonance imaging, colloid cysts (CCs) are discovered more frequently and subsequently their true incidence exceeds the numbers previously estimated. In 1986, the first familial case was reported in two identical twin brothers. To date, a total of 17 of these cases have been reported, all differing in the pattern of affected family me...