In the present study, we provided synthesis of a series R-(+)- and S-(-)-limonene-based thiosemicarbazones containing different pentacyclic heterocyclic nucleus moiety focused in search novel antitumor antileishmanial agents. assay, derivative imidazole S-(-)-limonene 8 was most active compound, especially for U-251, UACC-62 K562 human tumor cell lines with GI50 ranging from 1.0 to <0.25 µg....