The present study evaluated the effects of histamine 10(-2) M on longitudinal preparations of rat portal vein. It was observed that histamine 10(-2) M induced relaxation of rat portal vein preparations pre-contracted with phenylephrine 10(-4) M. On the other hand, no pharmacological effects were observed in preparations not pre-contracted. The observed histamine-induced relaxing effect was abse...

AFTER the second world war, the emigration of peoples from Europe to Australia was greatly accelerated. The large numbers of these different national groups now resident in Australia has permitted investigations of different disease incidence among them. During the examination of over 300 patients who had angle-closure glaucoma (in one of its forms previously described by Lowe, 1961), it was po...

OBJECTIVE There is evidence from animal studies that fluoxetine may enhance the concentrations of neuroactive steroids. Therefore, the authors investigated whether clinically effective treatment with antidepressants may alter the concentrations of neuroactive steroids in patients suffering from a major depressive episode. METHOD In the first study, eight drug-naive outpatients with major depr...

Using HPLC on a partisil column (5 nm) it was possible to separate two reaction products from an enzyme incubation of dimethylallylpyrophosphate and 3,6a,9-trihydtoxypterocarpan with a particulate fraction from elicitor-treated soybean cotyledons (Harosoy 63) or soybean cell cultures. These two products were identified by MS and !H-NMR analysis as 2and 4-dimethylallyltrihydroxypterocarpan. Both...

Agonist-independent activity of G-protein-coupled receptor, also referred to as constitutive activity, is a well-documented phenomenon and has been reported recently for both the histamine H(1) and H(2) receptors. Using SK-N-MC cell lines stably expressing the human and rat H(3) receptors at physiological receptor densities (500-600 fmol/mg of protein), we show that both the rat and human H(3) ...

BACKGROUND Traditional health practitioners (THPs) play a vital role in the health care of the majority of the South African population and elsewhere on the African continent. However, many studies have challenged the role of THPs in health care. Concerns raised in the literature include the rationale, safety and effectiveness of traditional health practices and methods, as well as what informs...

In mice, only the paternal allele of the Igf2 gene, encoding insulin-like growth factor II (IGF-II) is expressed due to parental imprinting. Interestingly, the Igf2r gene, which encodes one of the two known receptors (IGF2R) to which IGF-II binds with high affinity is also subject to imprinting, but in a reciprocal fashion. This observation raises the possibility that imprinting of these loci s...

Drug Metabolism & Pharmacokinetics (YM, SCK, CECAH, DZ), Discovery Chemistry (PSD, THP), Translational Oncology (SY, AP), Protein Chemistry (HKE), Development Toxicology (HW), Genentech, South San Francisco, CA 94080, USA. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on September 28, 2016 as DOI: 10.1124/dmd.116....