نتایج جستجو برای: thiamin deficiency
تعداد نتایج: 138045 فیلتر نتایج به سال:
Experiments are reported upon young rhesus monkeys which were given a diet essentially the same as the Goldberger black tongue-producing diet, supplemented in various ways. Those receiving the unsupplemented diet developed the syndrome characterized by leucopenia, anemia, gingivitis, diarrhea, and death, which has been previously described in monkeys receiving our diet of refined foodstuffs. An...
Although the structure of thiamin (vitamin B,) has been known for over 40 years (Williams, 1936; Grewe, 1936) and its chemical synthesis accomplished soon thereafter (Williams & Cline, 1936; Andersag & Westphal, 1937; Todd & Bergel, 1937), the biosynthetic pathway to thiamin (3) has still not been elucidated completely. It is well established that the pyrimidine (1) and thiazole (2) moieties ar...
Activation of the coenzyme ThDP was studied by measuring the kinetics of deprotonation at the C2 carbon of thiamin diphosphate in the enzymes pyruvate decarboxylase, transketolase, pyruvate dehydrogenase complex, pyruvate oxidase, in site-specific mutant enzymes and in enzyme complexes containing coenzyme analogues by proton/deuterium exchange detected by 1H-NMR spectroscopy. The respective dep...
Biofortification of staple crops like potato via breeding is an attractive strategy to reduce human micronutrient deficiencies. A prerequisite is metabolic phenotyping of genetically diverse material which can potentially be used as parents in breeding programs. Thus, the natural genetic diversity of thiamin and folate contents was investigated in indigenous cultivated potatoes (Solanum tuberos...
OBJECTIVE The present study aimed to review the literature on micronutrient deficiency and other factors influencing a deficiency status among children living in China. DESIGN A systematic review was performed to analyse the literature. SETTING Studies were identified through a search of PubMed and secondary references. SUBJECTS Children living in China aged less than 18 years. RESULTS ...
BACKGROUND Infantile beriberi is a potentially lethal manifestation of thiamin deficiency, associated with traditional post-partum maternal food avoidance, which persists in the Lao PDR (Laos). There are few data on biochemical markers of infantile thiamin deficiency or indices of cardiac dysfunction as potential surrogate markers. METHODOLOGY/PRINCIPAL FINDINGS A case control study of 47 inf...
Man has a limited capacity to absorb riboflavin (1-3) and thiamin (4, 5). The gastrointestinal absorption of these vitamins is describable by Michaelis-Menten type kinetics, characteristic of saturable, specialized absorption processes (6). Both vitamins are phosphorylated in the intestinal mucosa during absorption (7-9) and there is evidence suggesting that this process is the basic mechanism ...
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