LC8 is a highly conserved light-chain subunit of cytoplasmic dynein that is thought to play a fundamental role in both the assembly of the motor complex and the recruitment of cargo. An interaction between LC8 and the Drosophila protein swallow has been previously characterized and supports a role for dynein in the localization of maternal morphogens during oogenesis. Swallow is required for th...

PURPOSE OF REVIEW We provide an overview of the clinical application of novel pharyngeal high-resolution impedance manometry (HRIM) with pressure flow analysis (PFA) in our hands with example cases. RECENT FINDINGS In our Centre, we base our interpretation of HRIM recordings upon a qualitative assessment of pressure-impedance waveforms during individual swallows, as well as a quantitative ass...

There are an estimated 40% of people who have dysphagia (eating, drinking and swallowing problems) following stroke. This figure does not include populations who develop dysphagia due to other disease processes such as Parkinson’s disease and dementia. The risks of dysphagia include; developing aspiration pneumonia, malnutrition and dehydration. Management of dysphagia includes provision of mod...

42 Mammalian swallowing involves the coordinated and sequential activity of 43 many oropharyngeal muscles. Using synchronous electromyography and 44 videofluorography, we recorded the pattern of EMG activity for 12 muscles during 45 swallowing in neurologically intact suckling pigs. We tested the hypothesis that 46 this EMG pattern corresponded to the established pattern of activity for the 47 ...

A 59-year-old man presented with a one-year History of progressive dysphagia to the point that he could no longer swallow solid foods. Cervical spine X-Ray Elms demonstrated massive anterior new bone formation along the anterior surface of C3 to C7 vertebrae. Evaluation with barium swallow and cervical computed tomograhpy demonstrated oesophageal compression. Resection of the anterior onteophyt...