I nhaled nitric oxide (NO) has long been known to be an effective pulmonary vasodilator in the normal pulmonary vasculature. In the classical NO signalling pathway, it activates soluble guanylate cyclase in the cytoplasm of pulmonary artery smooth muscle cells, leading to the production of cyclic guanosine monophosphate (cGMP), which then activates protein kinase G (PKG). PKG, acting through se...

Military commanders face challenges that their counterparts in the business world would confront only in the rarest of circumstances. Commanders must make decisions that place their human and equipment resources in harm’s way. When a commander or senior civilian military decision-maker must commit to an action that endangers the lives of his or her troops, their decisions and the information or...

of OPERATIONAL FIRES ON THE URBAN BATTLEFIELD: AN UNDERDEVELOPED CONCEPT The US military will continue to be confronted in asymmetric warfare by adversaries who establish their power centers in urban terrain. Recent history has demonstrated that US forces can defeat adversaries on the conventional battlefield through overwhelming tactical and operational fires. Specifically, the employment of o...

Commander, Coast Guard Sector Baltimore. (2) Official Patrol means any vessel assigned or approved by Commander, Coast Guard Sector Baltimore with a commissioned, warrant, or petty officer on board and displaying a Coast Guard ensign. (3) Participant includes all vessels participating in the 2007 Cambridge Offshore Challenge under the auspices of the Marine Event Permit issued to the event spon...

I would like to thank the American Association for the Surgery of Trauma and President Cryer for the opportunity to deliver the 2004 Fitts Lecture. When Dr. Cryer asked me to deliver this lecture, I actually wondered whether he had called the wrong number. Dr. Basil Pruitt described Dr. William P. Fitts in his 1992 Fitts Lecture as a ‘physician soldier in World War II, an author, a chairman, an...