background: human t-lymphotropic virus type i is the etiologic agent of two distinct human diseases, adult t-cell leukemia or lymphoma and a chronic, progressive demyelinating disorder. the aim of this work was to investigate the seroprevalence of htlv-1/2 among high risk patients (thalassemic and hemodialysis) in charmahal-va-baktiari province, center of iran. methods: using elisa, a total of ...

objective febrile seizure is the most common seizure disorder in children. its pathophysiology is not fully understood yet; however, some risk factors have been cited for it. iron is one of these influential elements and is involved in the metabolism of some neurotransmitters which are reduced in irondeficiency anemia and also increases the sensitivity of neural cells during a febrile episode. ...

BACKGROUND Thalassemic disorders are the most prevalent monogenic hereditary diseases around the world caused by decreased and altered synthesis or agenesis in one or more globin chains. Families who have a child with thalassemia major face a myriad of significant problems. Hormozgan province ranks second with thalassemic patients in Iran. Therefore, current research is aimed to analyze the rep...

We studied the nature of enucleated RBCs containing DNA remnants, Howell-Jolly (HJ) RBCs and reticulocytes (retics), that are characteristically present in the circulation of thalassemic patients, especially after splenectomy. Using flow cytometry methodology, we measured oxidative status parameters of these cells in patients with β-thalassemia. In each patient studied, these cells had higher c...

Anemia in beta-thalassemia is caused by a combination of ineffective erythropoiesis and premature hemolysis of RBC in the peripheral circulation. Excess of the alpha-globin chain present in beta-thalassemic RBC is mainly responsible for oxidative damage of erythrocyte membrane protein. The activities of glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase, and glutat...

This paper presents the use of a genetic programming (GP) system called STROGANOFF and a multilayer perceptron for thalassemic patient classification. The interested problem covers the test samples from normal subjects and that from different types of thalassemic patient and thalassemic trait. The features, which are the characteristics of red blood cell, Thalassemic Patient Classification Usin...

OBJECTIVE To investigate puberty in a group of thalassemic patients with delayed or arrested pubertal development and to compare the effects of hormonal and L-carnitine therapy on puberty in those patients. PATIENTS Thirty-two -thalassemic patients with arrested or failure of puberty were enrolled for 1 year in this study. METHOD Clinical pubertal assessment and laboratory investigations we...

BACKGROUND Iron overload in patients with thalassemia is a common feature which requires continuous chelation therapy and monitoring. Serum ferritin determination is widely accepted as a simple method for following iron load in patients with primary hemochromatosis; however, several reports on thalassemic patients emphasize that ferritinemia is not accurate and that other methods such as direct...

PURPOSE To determine the prevalence and geographic distribution of thalassemia and to evaluate the success of the thalassemia prevention and treatment programs in Iran. METHODS Data were obtained from the National Thalassemia Registry of Iran, Iranian Blood Transfusion Organization, genetic laboratories involved in prenatal diagnosis, related pharmaceutical companies, and centers performing b...

Background: Thalassemic syndroms are the most common genetic disease in the world that related to blood transfusion and iron overload in the body. Cardiac complications are the leading cause of death in patients with thalassemia. Cardiovascular complications in patients largely decreases with iron chelators medications. In this study effect, complications and acceptance of iron chelator therapy...