INTRODUCTION Data from the SINGLE trial demonstrated that 88% of treatment-naive HIV-1 patients treated with dolutegravir and abacavir/lamivudine (DTG+ABC/3TC) achieved viral suppression at 48 weeks compared with 81% of patients treated with efavirenz/tenofovir disoproxil fumarate/emtricitabine (EFV/TDF/FTC). It is unclear how this difference in short-term efficacy impacts long-term cost-effect...

Oxygen species generated by human polymorphonuclear leukocytes (PMNs) activated by 12-0-terradecanoylphorbol-13-acetate (TPA) caused the formation of 5-hydroxymethyl-2'-deoxyuridine (HMdUrd), and (+) and (-) diastereoisomers of ri.v-th) midinc glycol (dTG) in DNA that was exposed to them. There were 9 HMdUrds and 31 dTGs formed per 1 x 10* thymidine residues. When Fe(II)/ethylenediaminetetraace...

Europium (III) complex with anthracene-9-carboxylic acid (9-AA) has been synthesized and characterized by elemental analysis, FT-IR, and TG-DTG techniques. The results indicated that the composition of this complex is Eu (9-AA)(3). The luminescence properties of the complex in different solvents and at different pH values have been investigated. The results show that the complex exhibits more e...

Complexes of phosphated cornstarch and waxy cornstarch with casein were prepared and characterised. They were prepared from casein in defatted milk and corn and waxy corn starches phosphated to degree of substitution values (DS) of 0.0637 and 0.0968, respectively. The components were blended in starch to casein ratios of 2:1, 1:1, and 1:2, then precipitated with hydrochloric acid. Aqueous solub...

A new dinuclear complex, [Ni(2)(H(2)O)L(4)].5H(2)O, consisting of chelating bidentate and bridging tridentate coordinated 2-[(4-methylphenylimino)methyl]-6-methoxyphenol (HL) Schiff base ligands and water molecules has been synthesized using a traditional method. The structure of this complex was characterized by FTIR and UV/Vis spectroscopy and thermogravimetric analyses (TG-DTG) and further c...

Um planejamento fatorial foi aplicado para avaliar o conteúdo de cinzas em mel pela termogravimetria bem como para estabelecer as condições de análise ótimas que produzem conteúdos de cinzas em concordância com aqueles obtidos pelo método oficial (gravimetria). Os efeitos de taxa de aquecimento e papel de fibra de vidro foram significativos bem como o efeito de interação entre estas variáveis. ...

INTRODUCTION Drug resistance against dolutegravir (DTG) or the nucleosides with which it has been co-administered has never been observed in patients receiving this drug in first-line therapy. In contrast, a R263K mutation that confers low-level resistance (3-4 fold) to DTG has been selected by DTG in culture. Our group has ascribed the absence of resistance to DTG to the high fitness cost exac...

A Chinese hamster ovary cell mutant DTG 1-5-4, was selected for pleiotropic defects in receptor-mediated endocytosis by methods previously described (Robbins, A. R., S. S. Peng, and J. L. Marshall, 1983, J. Cell Biol., 96:1064-1071). DTG 1-5-4 exhibited increased resistance to modeccin, Pseudomonas toxin, diphtheria toxin, Sindbis virus, and vesicular stomatitis virus, as well as decreased upta...

T-modulated differential scanning calorimetry measurements on bulk AsxSe12x glasses show that the glass transition temperature Tg(x) variation at x,0.12 is linear with a slope dTg /dx54.1 °C/at.% As, and the nonreversing heat flow, DHnr(x) almost vanishes in the 0.291~1!,x,0.37~1! composition range. These thermal results analyzed by agglomeration theory and constraint theory suggest that in add...

Two hemicellulose fractions were obtained by extraction of one-monthold young bamboo (Phyllostachys pubescens Mazel). The fractionation procedure employed 2% NaOH as extractant, followed by filtration, acidification, precipitation, and washing with 70% ethanol solution. The total yield was 26.2%, based on the pentosan content in bamboo. The physicochemical properties were determined and sugar c...