Photochemistry provides a wide range of alternative reagents that hold potential for use in bimolecular functionalisation proteins. Here, we report the synthesis and characterisation metal ion binding chelates derivatised with disubstituted tetrazoles photoradiochemical labelling monoclonal antibodies (mAbs). The photophysical properties featuring extended aromatic systems auxochromic substitue...

Montmorillonite KSF has been used as an effective and non-toxic heterogeneous catalyst for one-pot synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition of sodium azide with a wide variety of nitriles. The reaction afforded high yields of the desired products in a short reaction time under mild reaction conditions. The catalyst can be recovered by simple filtration and reuse...

5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...

Cycloadditions of azides with alkynes to form triazoles under thermal conditions (Huisgen cycloaddition) or in the presence of copper [click reaction, copper-catalyzed azide– alkyne cycloaddition (CuAAC)] are reactions of fundamental importance in organic chemistry. Triazoles can also be obtained by means of ruthenium, silver, and iridium catalysis, as well as by a zinc-mediated process. In sha...

The necessity of anti-inflammatory drugs such as glucocorticoids has been evident during the COVID-19 pandemic. Glucocorticoids, are standard therapy for treatment moderate and severe patients. However, serious side effects limit use these drugs, with better pharmacological properties urgently required. Bile acids interest, because their immunomodulatory properties, facilitated through an uncle...