BACKGROUND Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998-399. Prostaglandin D2 (PGD2) is a bronchoconstriction inducing metabolite of arachidonic acid in the mast cells, which is produced on exposure to allergens and acts as a ligand for the Prostaglandin D2 Receptor (PTGDR). Polymorphisms in the PTGDR gene have been suggested to be i...

BACKGROUND Vesicoureteral reflux (VUR) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys. OBJECTIVES The aim of this study was to determine whether the genetic polymorphisms of the IL-10, IL-12, and TNF-α genes are involved in the development of VUR. PATIENTS AND METHODS The tetra amplification mutation refrac...

The most studied single nucleotide polymorphisms of the VDR gene are Bsm1, Apa1, Taq1 and Fok1. Previously, many approaches have been used to study SNPs in VDR gene including restriction fragment length polymorphism (RFLP), Single Amplification refractory mutation system PCR (Single-ARMS-PCR), and sequencing of the VDR gene. The objective of the study was to develop a multiplex ARMS-PCR system ...

Oxidative stress has been recognized to be associated with melanoma. We have previously shown that ankyrin repeat-rich membrane spanning (ARMS), a tetra-spanning transmembrane protein, was overexpressed in melanoma cells and conferred resistance hydrogen peroxide (H2O2)-induced cell death. To explore the molecular mechanism of ARMS under oxidative stress, we established ARMS-knockdown (siARMS) ...

In the title mol-ecule (systematic name: methane-tetra-yltetra-methyl-ene tetra-p-toluene-sulfonate), C(33)H(36)O(12)S(4), the central C atom and the S atoms exhibit distorted tetra-hedral configurations. The aromatic rings in opposite arms are nearly parallel to each other, with a dihedral angle of 10.26 (8) or 3.45 (9)°. The mol-ecules are linked into a two-dimensional network parallel to the...

background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...