BACKGROUND Gliomas are the most common human brain tumors. Glioblastoma, also known as glioblastoma multiform (GBM), is the most aggressive, malignant, and lethal glioma. The investigation of prognostic and diagnostic molecular biomarkers in glioma patients to provide direction on clinical practice is urgent. Recent studies demonstrated that abnormal DNA methylation states play a key role in th...

Thi s pape r describes a n app lication of tes ting methodology a nd te c hniques de ve loped by th e a uthors to a id in impro vi ng the qu a lity of mathem ati ca l soft wa re. These techni q ues diffe r rad ica ll y in se vera l as pects from techni q ues pre vious ly used . the most import a nt d iffere nce be ing th at th e testin g is not based e xc lus ivel y Oil random a rgume nt s. Ins...

Transposable elements (TEs) are a dominant feature of most flowering plant genomes. Together with other accepted facilitators of evolution, accumulating data indicate that TEs can explain much about their rapid evolution and diversification. Genome size in angiosperms is highly correlated with TE content and the overwhelming bulk (>80%) of large genomes can be composed of TEs. Among retro-TEs, ...

Using expression cloning to screen a human fetal kidney cDNA library for regulator(s) of pro-matrix metalloproteinase (MMP)-2 processing mediated by membrane-type (MT) 1 MMP, we isolated a cDNA whose product interfered with pro-MMP-2 activation. It encodes the NH(2)-terminal 313-amino acid region of a calcium-binding proteoglycan, testican 3, with a 3-amino acid substitution at the COOH terminu...

This chapter will (1) briefly review selected studies examining the nature of thought experiments in science; (2) review previous studies on the role that thought experiments can play in science instruction; (3) give case study examples of thought experiments (TEs) proposed by both teachers and students and the ensuing classroom discussions. We discuss several definitions for the term thought e...

This paper investigates the effect of low penetration rate on mobile phone-based traffic state estimation (M-TES) models. Synergistic approaches, including an appropriate genetic algorithm (GA) based velocity–density estimation model and a notable artificial neural network (ANN) based prediction method for unacceptably low penetration rate, are proposed. The GA-based traffic state estimationmod...

Swedish nuclear plants are slowly being shut down as a result of a referendum in 1980. This was one starting point for the thermal energy storage (TES) expansion in Sweden. Now, the new EU directive on energy efficient buildings forces HVAC engineers and civil engineers to look for new methods to reduce electricity consumption and to improve energy performance in new and existing buildings. Thi...

The accurate detection and classification of network anomalies based on traffic feature distributions is still a major challenge. Together with volume metrics, traffic feature distributions are the primary source of information of approaches scalable to high-speed and large scale networks. In previous work, we proposed to use the Tsallis entropy based traffic entropy spectrum (TES) to capture c...

Transposable elements (TEs) are a dominant feature of most flowering plant genomes. Together with other accepted facilitators of evolution, accumulating data indicate that TEs can explain much about their rapid evolution and diversification. Genome size in angiosperms is highly correlated with TE content and the overwhelming bulk (>80%) of large genomes can be composed of TEs. Among retro-TEs, ...