The Osteosarcoma Surveillance Study, an ongoing 15-year surveillance study initiated in 2003, is a postmarketing commitment to the United States (US) Food and Drug Administration to evaluate a potential association between teriparatide, rhPTH(1-34), a recombinant human parathyroid hormone analog (self-injectable medication to treat osteoporosis), and development of osteosarcoma in response to a...

BACKGROUND Individuals with osteoporosis and recent vertebral fractures suffer from pain and impaired health-related quality of life (HRQL). To determine whether patients with osteoporosis treated with teriparatide experienced improvement in HRQL and pain symptoms after several months of therapy. METHODS We retrospectively studied a sample of osteoporosis patients treated with teriparatide in...

INTRODUCTION Several factors associated with bone mineral density (BMD) increase are reported with daily teriparatide treatment, but there has been no systematic analysis to summarize these associations. The purpose of this study was to investigate the clinical determinants associated with BMD increase to daily teriparatide treatment. METHODS This was a retrospective study. We performed an an...

Incidences of osteoporosis and fragility fractures are constantly increasing, which are associated with increased morbidity and mortality. When these patients undergo surgery, a higher number of postoperative complications may be expected because of poor bone quality and delayed healing. As a result, poorer primary stability of the implant, initial loosening, and impaired fixation strength in d...

PURPOSE To evaluate the current evidence in the literature on treatment strategies for degenerative lumbar spine fusion in patients with osteoporosis. METHODS A systematic review of the literature from 1950 to 2015. RESULTS The review of the literature yielded 15 studies on the effect of treatment options for osteoporosis on lumbar fusion rates. This study evaluated only degenerative lumbar...

Osteoporosis associated with pregnancy and lactation is a less commonly known condition and often overlooked. The prevalence, exact aetiology and its pathogenesis are unknown. It is commonly seen in first three months after delivery in primigravida. It is often undiagnosed because of it not suspected n and X-rays and densitometry are avoided if possible during pregnancy and lactation. If missed...

RATIONALE Fracture nonunion is a great challenge for orthopedic surgeons. Many surgical interventions are associated with significant pain and heavy economic burden. Therefore, our aim was to evaluate the outcomes of a new nonoperative treatment for fracture nonunion. PATIENT CONCERNS A 44-year-old man suffered closed fractures of the right tibia and left femur. Eleven months after surgery, t...

IL: interleukin NR: normal range PAPA: pyogenic sterile arthritis, pyoderma gangrenosum, and acne PTH: parathyroid hormone SAPHO: synovitis, acne, pustulosis, hyperostosis, and osteitis WBC: white blood cell INTRODUCTION Autoinflammatory syndromes are an incompletely understood spectrum of diseases that involve spontaneous inflammation caused by genetic variants of the innate immune system. Unl...

OBJECTIVES To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms.  Methods: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center...

several important points that deserve comment. The primary objective of our paper was to report the results of a standard two-year rat carcinogenicity study conducted with recombinant full-length human PTH (1-84) to comply with international regulatory guidelines. Dr. Vahle et al. are correct that our study did not directly compare the carcinogenic potential of PTH (1-84) and PTH (1-34), that i...