subnormal responses found in patients given interriittent COT ticosteroid therapy by Malone et al. (1970). This finding, together with the satisfactory clinical response in these patients with severe disease, suggests that a therapeutic trial of depot tetracosactrin in a dose of 0-5 mg twice weekly should be considered for the control of disease requiring steroid therapy over a prolonged period...

Inhaled short-acting beta2-agonists provide greater protection against airway responsiveness (AR) to the mast-cell stimulus, adenosine 5'-monophosphate (AMP), than to histamine, a direct spasmogen. Both terbutaline and albuterol exhibit this mast-cell stabilizing property in a dose-dependent manner. A single dose of the long-acting beta2-agonist formoterol has also been reported to have a mast ...

Baloğlu E, Ke A, Abu-Taha IH, Bärtsch P, Mairbäurl H. In vitro hypoxia impairs 2-adrenergic receptor signaling in primary rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 296: L500 –L509, 2009. First published December 19, 2008; doi:10.1152/ajplung.90390.2008.—Hypoxia inhibits 2-adrenergic receptor ( 2-AR) signaling in a variety of tissues, but effects in alveolar epithelium ar...

beta-Adrenergic agonists (beta-agonists) are commonly used to treat respiratory syncytial virus (RSV) bronchiolitis but are generally ineffective for unknown reasons. We have previously shown that RSV strain A2 inhibits bronchoalveolar epithelial responses to beta-agonists in a BALB/c mouse model by inducing heterologous keratinocyte cytokine (KC)/CXCR2-mediated desensitization of epithelial be...

Carranza, Andrea, Susana Nowicki, Marta Barontini, and Ines Armando. L-Dopa uptake and dopamine production in proximal tubular cells are regulated by b2adrenergic receptors. Am J Physiol Renal Physiol 279: F77–F83, 2000.—This study assessed the role of adrenergic receptors on the regulation of the uptake of L-dopa and the production of dopamine by renal tubular cells. Scatchard analysis showed ...

I read with interest the case report (Spielberg and van Denbrink, Eur Respir J., 1, 471-472) from Davos on a patient with brittle asthma treated with a continuous infusion of theophylline. I was surprised to see that our paper on the treatment of brittle asthma with continuous subcutaneous infusions of terbutaline was not referred to [1]. Since that preliminary study which showed excellent cont...

The bronchodilator response to cumulative doses of terbutaline administered by metered dose inhaler with and without a conical spacer device and by Acorn nebuliser has been compared in groups of patients with chronic severe and moderately severe asthma. After laboratory studies the patients undertook a randomised domiciliary crossover comparison of bronchodilator response to terbutaline given b...