While cimetidine (CIM) is strikingly effective in inhibiting gastric acid secretion, its effect on the defensive mechanisms of the gastric mucosa has been controversial. The aims of the present study were to test if administration of CIM at an antisecretory dose is protective against acid-induced injury and to assess its effect on adaptive cytoprotection induced by non-necrotizing concentration...

BACKGROUND Case reports suggest that hairy cell leukemia (HCL) may be associated with autoimmune conditions, however no systematic investigations in this area have been undertaken. METHODS Using the United States Surveillance, Epidemiology, and End Results Medicare linked database, we conducted an exploratory study comparing autoimmune conditions in 418 HCL cases (aged ≥65 years) and 160,086 ...

We describe the clinical and laboratory features of 17 adult patients with a variant form of hairy cell leukemia (HCL-V) studied over the last 7 years. The main findings were: splenomegaly, moderate anemia, thrombocytopenia, and a raised white blood cell count (median 116 x 10(9)/L; range 15 to 482). The circulating lymphoid cells had abundant villous cytoplasm and a round, occasionally bilobed...

Although increased cholesterol synthesis is a feature of many types of human leukemic cells, cells from patients with chronic lymphocytic leukemia have a low cholesterol content and display normal rates of cholesterol synthesis when compared with normal human peripheral blood mononuclear cells (PBMNC). In contrast, Ieukemic cells from patients with hairy cell leukemia (HCL). another chronic B-c...

Two simple spectrophotometric methods have been developed for simultaneous estimation of drotaverine hydrochloride and aceclofenac from tablet dosage form. Method I is a simultaneous equation method (Vierodt's method), wavelengths selected are 306.5 and 276 nm. Method II is the absorbance ratio method (Q-Analysis), which employs 298.5 nm as λ(1) and 276 nm as λ(2) (λmax of AF) for formation of ...

The scalpellomorph barnacle, Aurivillialepas calycula (Aurivillius, 1898), previously known only from Macaronesia, is reported from Banco de Galicia, off the NW corner of the Iberian Peninsula. One of the two specimens was attached to the scleractinian coral, Madrepora oculata Linnaeus, 1758. Since such pedunculate barnacles are little known, the potentially hermaphroditic specimens and its com...

This paper gives an integrable hierarchy of nonlinear evolution equations. In this hierarchy there are the following representative equations: ut = ∂ 5 xu − 2 3 , ut = ∂ 5 x (u 1 3 )xx − 2(u 1 6 )x u ; uxxt + 3uxxux + uxxxu = 0. The first two are in the positive order hierarchy while the 3rd one is in the negative order hierarchy. The whole hierarchy is shown integrable through solving a key 3×...

Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 -652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancers. However, the overall reported studies have shown inconsistent conclusions. ...

HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral blood (eight cases) of 16 patients with the B-cell form of HCL was probed. No...