Artificial corneas or keratoprostheses are intended to replace diseased or damaged cornea in the event that vision cannot be restored using donor cornea tissue. A new class of artificial cornea comprising a combination of poly (2-hydroxyethyl methacrylate) and poly (methyl methacrylate) was developed which was fabricated using a gas foaming technique. Referred to as the gas-foamed KPro, it was ...

Anatomically, the cornea is the outermost layer of the eye and is primarily responsible for light refraction which allows for central and peripheral vision. Corneal diseases are among the major causes of global blindness, secondary to cataracts. This paper Keratoprosthesis (OOKP), which is a two stage procedure whereby dental and buccal tissue is auto transplanted into eye to serve as a synthet...

Silicone oil continues to be an important aid in retinal detachment surgery. We report a case in which disparate responses to silicone oil were noted in the conjunctiva and intraocularly. Intraocularly, the oil permeated a fibrous membrane that formed behind a keratoprosthesis, the first example of this phenomenon. We detail the histological response to the oil at this site as well as a distinc...

Chemical injuries are increasing in the modern world. Acids and alkalis are the main chemicals implicated. In this review article, the author has outlined the pathogenesis of the damage inflicted by acids as well as alkalis. Emergency treatment has been described as well as treatment to be used in the acute, sub -acute and chronic phases to reduce morbidity in these cases Modern methods of mana...

PURPOSE OF REVIEW To review emerging indications for the Boston keratoprosthesis (KPro) and to discuss current research underway to improve clinical outcomes. RECENT FINDINGS In addition to multiple failed corneal grafts, other ocular conditions for which the Boston KPro has been used include herpetic keratitis, aniridia, autoimmune ocular disorders, and pediatric corneal opacities. In the re...

PURPOSE We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications. METHODS Cylindrical rods were made of poly(methyl methacrylate) (PMMA), PMMA coated with titanium dioxide (TiO2) over a layer of polydopamine (PMMATiO2), smooth (Ti) and sandblasted (TiSB) titanium, and titanium t...

PURPOSE To evaluate the use of the Boston keratoprosthesis (KPro) in patients with Stevens-Johnson syndrome (SJS). DESIGN Retrospective, noncomparative, interventional case series. METHODS Sixteen eyes of 15 patients with SJS underwent KPro surgery at the Massachusetts Eye and Ear Infirmary from January 2000 through December 2005. The preoperative, operative, and postoperative findings were...

The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(m...