In this issue of Blood, Sørensen et al observe a functional indoleamine 2,3-dioxygenase (IDO)–specific CD8 T-cell population in humans.1 IDO-specific CD8 T cells are capable of killing IDO cells. Given that IDO expression is induced in physiologic and pathologic immune responses, and that IDO-expressing cells may temper immune activation, this work suggests an important role for IDO-specific CD...

Nom.nel.tuN 110.03 Gear-Tooth Wear and Failure (USAS 86.12-1964) Jan. 1962 DunblJity 21S.JI Information Sheet for Surface Durability (Pitting) of Spur, Helical. Herringbone and Bevel Gear Teeth Sept. 1966 217.01 lntcrrnancn Sheet·Gear Scoring Design GUide for Aerospace Spur and Helical Power Gears Oct. 1965 Strentth 225.Q1 Information Sheet for Strength of Spur. Helical, Hernngbone and Bevel Ge...

Prader-Willi syndrome (PWS) is associated with an insatiable appetite and (often) other maladaptive behaviours (self-injury, sleep disorders, insistence on routines, and temper tantrums). Psychoses are not a recognised feature. Most affected people have a chromosome 15 abnormality (deletion, disomy, structural rearrangement, etc.). Three people with PWS who developed psychotic disorders in earl...

Attention-deficit hyperactivity disorder (ADHD) is probably the most common chronic undiagnosed psychiatric disorder in adults. It is characterized by inattention and distractibility, restlessness, labile mood, quick temper, overactivity, disorganization, and impulsivity. It is always preceded by the childhood diagnosis, a disorder that is rarely inquired about, and usually overlooked. Treatmen...