INTRODUCTION We previously reported that in HIV-1 infected patients circulating Vdelta1 T lymphocytes (Vdelta1) increase and proliferate in vitro in response to Candida albicans (Ca). Herein, we analysed the effects of MF59 adjuvant on the Vdelta1 T cell responses to hemagglutinin (HA) and Ca in HIV-1 seropositive and seronegative adults after influenzal vaccine, to clarify th molecular mechani...

Abstract Background Previous studies have shown that EDCs may activate nuclear transcription factor, such as activator protein-1 (AP-1), factor of activated Tcells (NF-AT) and kappa B (NF-?B) in the process immune damage. At same time, some experts believed estrogen play an important role this process. As a typical representative EDCs, nonylphenol (NP) has not been reported. The aim work was to...

Purpose: Small cell lung cancer (SCLC) possesses high tendency to disseminate. However, SCLC patients with paraneoplastic syndromemediated by immunity against onconeural antigens remain in limited-stage disease (LD) without distant metastases. Cumulative evidence regulates that a balance between immune and regulatory T (Treg) cells determines the magnitude of immune responses to not only self-a...

Objective: Immune escape is a characteristic feature of head and neck squamous cell carcinoma (HNSCC). RegulatoryTcells (Treg) might contribute to HNSCC progression by suppressing antitumor immunity, and their attributes in patients are of special interest. Methods:Multicolor flow cytometry was used to study the frequency and phenotype ofTreg in peripheral blood lymphocytes of 35 patients with ...

A 73-yr-old man was evaluated for fever and multiple palpable nodules in his neck and inguinal areas. Biopsy of a cervical lymph node demonstrated polymorphic infiltrates including Tcells with abundant clear cytoplasm (clear cells), follicular dendritic cells, and plasma cells in the background of prominent arborizing high endothelial venules. The involved lymph node had typical histological an...

The outcomes of unrelated donor hematopoietic stem cell transplantation (HSCT) have substantially improved during the past decade. The reason for this is more sophisticated tissue typing and perhaps also better supportive care. However, graft-versus-host disease (GVHD) is a major cause of morbidity and mortality using unrelated donors. The risk of graft failure is also higher in unrelated donor...

Our previous publications (1, 2) indicated that thymocytes and spleen cells of mice that had been immunized with a high dose of carrier antigen, when transferred into syngeneic host, could suppress the antibody response against a hapten coupled to the homologous carrier . This suppressive effect was found to be mediated by a population of thymus-derived lymphocytes, whose activity was completel...

The majority of Hodgkin lymphoma (HL) patients can be cured with risk-adapted treatment, including chemotherapy and radiotherapy. Even when initially diagnosed with advanced-stage disease,.70% of these patients achieve long-term remission. However, depending on initial risk factors and treatment, 10% to 30% progress or relapse. Of these patients, only up to 50% can be cured with highdose chemot...

We have previously demonstrated that the curative effectiveness of a low dose (2.5 mg/kg) of melphalan (i.-phenylalanine mustard; L-PAM) for mice bearing a large s.c. (approximately 20 mm in diameter) MOPC315 tumor and extensive métastases requires the participation of T-celldependent antitumor immunity in tumor eradication (S. Ben-Efraim et al.. Cancer luminimi. Immunother., 15: 101-107, 1983...

Prostate cancer (PCa) is the second leading cause of death among men worldwide. Androgen signaling plays key roles in PCa progression [1], and so far available therapeutic agents mainly target androgens or androgen receptor (AR) [2]. However, the patients receiving these treatments often recurs with progression to castration resistant prostate cancer (CRPC) [3]. Metastatic CRPC (mCRPC) is the a...