Development of microspheres is a promising technology for controlled release and drug targeting. Various types such as bio-adhesive, magnetic, floating, radioactive polymeric are developed various purposes. Microspheres occupied central place in novel delivery. There departments medicine like cancer, pulmonary, cardiology, radiology, gynecology, oncology etc., where numerous drugs used delivere...

Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and ...

Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin recept...

objective(s): p-glycoprotein (p-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. although sirna delivery to reverse p-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of sirna requires effective carriers that can deliver sirna intracellularly with minimal toxicity on targe...

Drug delivery to the Central Nervous System (CNS) in treatment of CNS related disorders is very complicated and challenging. Although some neuropharmaceutical agents have great potential for treating CNS disorders, major challenge to CNS drug delivery is the Blood Brain Barrier (BBB), which limits the access of drugs to the brain. Progress in brain drug delivery has lagged behind other areas be...

A variety of ocular drug delivery systems, including a controlled release of the drug, drug targeting, and penetration enhancement of the drug, have been investigated. Biodegradable polymers have been widely used as the drug carrier for controlled-release systems. Biodegradable polymers release the drug as they themselves degrade and are finally absorbed within the body. Several ocular drug del...

The use of peptides to mediate the delivery and uptake of nanoparticle (NP) materials by mammalian cells has grown significantly over the past 10 years. This area of research has important implications for the development of new therapeutic materials and for the emerging field of NP-mediated drug delivery. In this review, we highlight recent advances in the delivery of various NPs by some of th...

Coating of liposomes with polyethylene-glycol (PEG) by incorporation in the liposome bilayer of PEG-derivatized lipids results in inhibition of liposome uptake by the reticulo-endothelial system and significant prolongation of liposome residence time in the blood stream. Parallel developments in drug loading technology have improved the efficiency and stability of drug entrapment in liposomes, ...

background: drug delivery systems related to different cancer therapy is now expanding. chitosan (cs) is currently receiving enormous interest for medical and pharmaceutical applications due to its biocompatibility in animal tissues. in this study two nanogels were prepared from chitosan. some of the critical factors such as controlling the release, adsorption and specially targeting drug deliv...

In article number 2001212 by Huile Gao, Xianchun Chen, and co-workers, recent progress of self-propelled micro/nanomotors for tumor drug delivery is reviewed. The force facilitates with autonomous movement, therefore exhibit potential enhanced efficiency in each step delivery, which includes circulation the blood, targeting, deep penetration, cellular internalization, release. combination thera...