The organisational context in which systems engineering is practised is changing. Organisations are becoming increasingly concerned with the flexibility of their processes. Fundamental issues of responsiveness to innovation in product concept, system architecture, component technologies and inter-working relationships are of growing importance. Current developments in management thinking and in...

Designing the representation languages for the input and output of a learning algorithm is the hardest task within machine learning applications. Transforming the given representation of observations into a well-suited language LE may ease learning such that a simple and eecient learning algorithm can solve the learning problem. Learnability is deened with respect to the representation of the o...

Tailored behavior change programs have proven effective at decreasing health risk factors, but the impact of such programs on participant well-being has not been tested. This randomized trial evaluated the impact of tailored telephone coaching and Internet interventions on health risk behaviors and individual well-being. Exercise and stress management were the primary health risks of interest; ...

Diffusive transport is characterized by the scaling law (length)^{2}∝(time). In this paper we show that this relationship is significantly altered in curved analog spacetimes. This circumstance provides an opportunity to tailor diffusion: by a suitable design of the analog metric, it is possible to create materials where diffusion is either faster or slower than in normal media, as desired. Thi...

Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected sign...

This brief paper is an elaboration on one section of Bezuidenhout (forthcoming).1 In the longer paper, I explore the relation between two conceptions of context, namely the psychologistic notion of a cognitive environment (CE) that belongs to the Relevance Theory (RT) framework and the formal notion of an index that belongs to the traditional Twentieth-century philosophy of language framework. ...

We present numerical results on Kau man's NK landscape family indicating that the optimal distance at which to search for tter variants depends on both the current tness and the sampling that can be a orded at each distance. The optimal search distance from average tness con gurations is large to escape local correlation limits and decreases as tness increases. An analytic derivation of the opt...