Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined how commonly occurring single site mutations in pathogenic fungi affect triazole binding using Saccharomyces cerevisiae Erg11p (ScErg11p) as a targ...

We analyze the queueing behavior of long-tailed traac ows under the Generalized Processor Sharing GPS discipline. GPS-based scheduling algorithms, such a s W eighted Fair Queueing, play a major role in achieving diierentiated quality-of-service in integrated-services networks. We prove that, in certain scenarios, a ow m a y be strongly aaected by the activity of`heavier'-tailed ows, and may inh...

We propose a new model for electricity prices that captures the heavy-tailed behavior that we observe in the hourly spot market in the Ercot (Texas) and the PJM West hub grids. We present a model according to which we separate the price process into a thin-tailed trailing-median process and a heavy-tailed residual process whose probability distribution can be approximated by a Cauchy distributi...

In order to trigger an adaptive immune response, T cells move through lymph nodes searching for dendritic cells that carry antigens indicative of infection. We observe T cell movement in lymph nodes and implement those movement patterns as a search strategy in a team of simulated robots. We find that the distribution of step-sizes taken by T cells are best described by heavy-tailed (Lévy-like) ...

This paper focuses on the competitive analysis of scheduling disciplines in a large deviations setting. Though there are policies that are known to optimize the sojourn time tail under a large class of heavy-tailed job sizes (e.g. Processor Sharing and Shortest Remaining Processing Time) and there are policies known to optimize the sojourn time tail in the case of light-tailed job sizes (e.g. F...

There is uncertainty regarding the validity of Myxobolus heterosporus Baker, 1963. The present study revises the taxonomy, using specimens isolated from plasmodia situated in the infected cornea of Oreochromis aureus, O. niloticus or Tilapia zillii inhabiting the River Nile, Egypt. In addition, histological effects of the parasite on the infected tissue were examined. The spores of M. heterospo...

We analyze the asymptotic behavior of long-tailed traffic sources under the Generalized Processor Sharing (GPS) discipline. GPS-based scheduling algorithms, such as Weighted Fair Queueing, have emerged as an important mechanism for achieving differentiated qualityof-service in integrated-services networks. Under certain conditions, we prove that in an asymptotic sense an individual source with ...

The restricted eigenvalue (RE) condition characterizes the sample complexity of accurate recovery in the context of high-dimensional estimators such as Lasso and Dantzig selector (Bickel et al., 2009). Recent work has shown that random design matrices drawn from any thin-tailed (subGaussian) distributions satisfy the RE condition with high probability, when the number of samples scale as the sq...

Several research efforts have recently attempted to characterize the effects of heavy-tailed traffic on router performance, while the effects of light-tailed traffic have for long been understood. Since general web traffic originates from heterogeneous sources, the study of traffic mixing is of importance as it can reveal the degree to which heavy-tailed traffic can be handled by networking inf...

We analyze the queueing behavior of long-tailed traac ows under the Generalized Processor Sharing (GPS) discipline. GPS-based scheduling algorithms, such as Weighted Fair Queueing, play a major role in achieving diierentiated quality-of-service in integrated-services networks. We prove that, in certain scenarios, a ow may be strongly aaected by the activity of`heavier'-tailed ows, and may inher...