Surfactants are frequently used to improve solubilization of lipophilic drugs. Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics. The antinociceptive effect of CrEL (3.2, 6.4 and 10.6 g/kg, in 10 ml...

calpastatin has been introduced as an effective candidate gene as regards growth efficiency and meat quality traits. throughout the present study, blood sampling as well as carcass trait measurements were performed on 74 lori-bakhtiari sheep and on 40 zel-atabay cross-breds from industrial slaughterhouses of shahrekord and gorgan cities, respectively. following dna extaction, polymerase chain r...

Problem statement: Oxidative stress plays a major role in hypercholesterolemia induced atherosclerosis. Garcinia atroviridis has been shown to exhibit antioxidant properties. Approach: The present study aimed to investigate the effect of Garcinia atroviridis on the oxidative stress in guinea pigs fed with high cholesterol diet. Twenty-four male Guinea pigs were divided into four groups. Group I...

alpha-Synuclein, an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded. Recent studies have demonstrated that alpha-synuclein has chaperone activity both in vitro and in vivo, and that this activity is lost upon removing its C-terminal acidic tail. However, the detailed mechanism of the chaperone action of alpha-synuclein remains unknown. In this st...

Within a conventional aircraft design process, the horizontal tail and vertical are generally sized via volume coefficient methods. In this manuscript, an improved method for conceptual based on multidisciplinary optimization (MDO) approach with stability control constraints has been developed. To develop method, first, requirements have derived from regulations fundamental functionalities of p...

A candidate marker that influences the flavor and odor of Indonesian sheep is Potassium Channel Tetramerization Domain Containing 2 (KCTD2) gene. This study aims to examine polymorphism association between KCTD2 gene lamb in local sheeps. used DNA taken from longissimus dorsi (LD) muscle 100 rams including 75 Javanese Thin-Tail (JTTS), 10 Fat-Tail Sheep (JFTS), 15 Jonggol (JS), with ranged weig...

Some strains of Pseudomonas aeruginosa produce R-type pyocins, which are high-molecular-weight phage tail-like protein complexes that have bactericidal activity against other Pseudomonas strains. These particles recognize and bind to bacterial surface structures via tail fibers, their primary spectrum determinant. R-type pyocins kill the cell by contracting a sheath-like structure and inserting...

Body, testis, and epididymis weights were recorded and homogenization-resistant sperm nuclei were counted to determine daily sperm production and the number of sperm stored within the cauda epididymis (CAUDASP) in 145 boars of a control line (C) and 128 boars of a line selected for increased predicted weight of testis (TS) at 150 d of age. Random samples of boars were evaluated at five ages bet...