A broad range of plant selections across the orange subfamily Aurantioideae were screened in solution and soil culture for their tolerance to low iron (Fe) stress. Young seedlings grown in soil were transferred to tubs of +Fe nutrient solution, which was later replaced after a brief period with a –Fe solution. Over several trials, ’20 white root tips were harvested periodically from the plants ...

Diabetes Mellitus has been becoming a disease of the century, and incidence is still rising worldwide. It causes many serious complications, especially in eye, heart, kidneys, brain, vascular system, such as diabetic nephropathy, retinopathy, liver fa­ilure, etc. Moreover, process controlling this complicated. Meanwhile, antidiabetic drugs on market are facing some problems with wide range adve...

Simulating the characteristics of electronic packages like thermal resistance, thermomechanical stress distribution and electromagnetics is important to guide and verify their design. Since packages consist of densely packed components of varied materials and shapes, the simulation time for generating their finite element analysis (FEA) models can span from hours to days. This paper overviews e...

•Single-cell RNA-seq data recapitulated sexual differentiation processes•Cell cycle state of developing germ cells was revealed by single-cell data•NANOS2 suppresses mTORC1 activators to induce cell arrest During murine development, male enter the mitotically arrested G0 stage, which is an initial step sexually dimorphic differentiation. The male-specific RNA-binding protein NANOS2 has a key ro...

•Aberrant acetylated regions (AARs) are an epigenetic barrier in SCNT embryos•TSA partly fixes AARs but is restricted by native epi-environments donor cells•Dux restores H3K9ac occupancy, drives 2C activation, and improves efficiency•Rescue efficiency Kdm4b TSA largely relies on Dux cluster activation Differentiated somatic cells can be reprogrammed to totipotent embryos through cell nuclear tr...

A combination of accelerator mass spectrometry (AMS) and liquid chromatography-tandem mass spectrometry has been used to clarify some new aspects of testosterone metabolism. The main pathway of testosterone oxidative metabolism by human liver microsomes is the formation of 1 -, 2 -/ -, 6 -, 15 -, and 16 hydroxytestosterones, mainly catalyzed by cytochromes P450 2C9, 2C19, and 3A4. We now report...

Subchronic administration of BR-16A (Mentat), a compound herbal formulation, and the nootropic agent, piracetam, augmented learning acquisition and retention of learning in normal rats, as well as in states of cognitive deficits induced by prenatal undernutrition, postnatal environment impoverishment and sodium nitrite hypoxia. The test paradigms used were step-down latency in a passive avoidan...

Autism is characterized by inappropriate social interactions, deficits in verbal communication and facial expressions, and ritualistic and repetitive behaviors. Recent evidence suggests the gaseous neurotransmitter nitric oxide (NO) may regulate certain behaviors characterized by autism-like symptoms. Inhibition of NO leads to hyperaggression and excessive mounting which may represent inappropr...

Esophageal cancer is one of the most difficult malignancies to cure. The prognosis remains unsatisfactory despite significant advances in surgical techniques and perioperative management. The optimal treatment strategy for localized esophageal cancer has not yet been established. Surgical resection remains the mainstay of treatment for esophageal cancer, and curative resection is the most impor...

The phosphoinositide 3-kinase (PI3K)/Akt pathway is commonly activated in cancer; therefore, we investigated its role in hypoxia-inducible factor-1A (HIF-1A) regulation. Inhibition of PI3K in U87MG glioblastoma cells, which have activated PI3K/Akt activity secondary to phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutation, with LY294002 blunted the induction of HIF-1A protei...