background : the main objective of this study was to design, formulate and evaluate the physicochemical properties of 500 mg acetaminophen effervescent tablets, in order to accelerate its analgesic and antipyretic effects in patients with pill swallowing problems. methods : formulations with 500 mg of acetaminophen were prepared with effervescent bases including tartaric acid, citric acid, sodi...

Objective(s): TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of...

Twelve proto-Elamite tablets and fragments were found during the 2006-07 excavation at Tape Sofalin in the northernCentral Iranian Plateau. The form and content of these tablets is entirely consistent with that of the standard and late proto-Elamite tablets from Susa, except TSF 11, which we date to the Susa II/GodinV Period. Although all of the inscribedobjects from Tape Sofalin published here...

Malabsorption of prednisolone administered as enteric coated tablets was suspected following therapeutic failure in an asthmatic. This was investigated by cortisol estimation and a Synacthen test and substantiated by the demonstration of abnormally low absorption of prednisolone from these tablets which nevertheless were normally absorbed by a volunteer. The absorption of prednisolone from conv...

Modified release formulations offer several advantages over conventional systems used in therapeutics. The aim of this work was to extend our previous studies on the chronobiotic hormone melatonin controlled release, by comparing its release from uncoated, compression-coated and bilayer tablets. Each tablet was comprised of melatonin and combinations of the following excipients: ethylcellulose,...

We attempted the development of rapid oral disintegration tablets by direct compression using co-ground mixture of D-mannitol and crospovidone. The co-ground mixture was prepared with a vibration rod mill. The tablets were formed by compression using a single punch-tableting machine after addition of the co-ground mixture to non-ground D-mannitol, crospovidone and magnesium stearate. Regarding ...

OBJECTIVE Our goal was to examine the daily average consumption (DACON) of oxycodone controlled-release tablets (OxyContin CR)and oxymorphone extended-release tablets (Opana ER) in patients with low back pain. STUDY DESIGN An observational, retrospective cohort study enrolled patients with multiple prescriptions for oxycodone CR or oxymorphone ER tablets. These patients also had International...