BACKGROUND A number of abnormalities has been identified among drug addicted users especially heroin addicts. However, there are a few studies to assess the opium effects on thyroid hormones. the aim of the present study is to investigate the effect of opium on the thyroid function tests. METHOD In this case-control, 50 male addicts, aged 20-50 years, with history of addiction to opium lastin...

A thyroid hormone analog with organ-selective effects could have therapeutic application for disorders such as hyperlipidemia and osteoporosis. We performed a randomized clinical trial to determine the specific thyromimetic effects of tiratricol. Twenty-four athyreotic patients underwent detailed metabolic and physiological evaluation after a 2-month baseline period, taking TSH-suppressive dose...

The mechanism of thyroid hormone (TH) secretion from the thyroid gland into blood is unknown. Humans and mice deficient in monocarboxylate transporter 8 (MCT8) have low serum thyroxine (T4) levels that cannot be fully explained by increased deiodination. Here, we have shown that Mct8 is localized at the basolateral membrane of thyrocytes and that the serum TH concentration is reduced in Mct8-KO...

Abstract − The research was conducted to examine the effects of saline-irrigation water on growth and fresh pod weight okra (Abelmoschus esculentus L.) under climatic conditions Kabul province, Af-ghanistan. This study consisted four treatments having different salinity levels irrigation water, (T1:0.0mM, T2:5mM, T3:10mM, T4:20mM), which were applied throughout growing season in plastic pots wi...

A clinical case of surgical treatment a female patient with dumbbell schwannoma growing from the T4 nerve root and aggressive hemangioma vertebral body arch is presented. The open kyphoplasty through posterior approach was performed followed by laminectomy, costotransversectomy at T4–T5 level on left, total microsurgical resection tumor right extrapleural approach, transpedicular fixation T3–T5...

Although hemangioendothelioma (HHE) is a commonly encountered hepatic tumor during infancy, HHE-related hypothyroidism is rare. We present a patient who developed HHE-related hypothyroidism during the neonatal period and showed marked improvement in hypothyroidism by regression of HHE. A 28-day-old boy with TSH level of 77 mIU/mL on neonatal screening and diagnosed as congenital hypothyroidism ...

The study was conducted to evaluate the effect of different levels of synthetic lysine (sLys) on dry matter intake (DMI), average daily weight gain (ADG), dry matter conversion ratio (DMCR), carcass characteristics and economics of productionof finisher broiler chicks. As 240 day-old broiler chicks were randomly distributed to 12 pens of 20 chicks each and assigned to four treatment rations in ...

Abstract We have evaluated the effects of different fish feeds on body composition, growth, and enzyme activities Labeo rohita (Rohu). In total, 240 fishes between average weights 24.77±2.15g were studied. The treatments applied in a completely randomized design, with 4 60 each. Treatments consisted four [Oryza (T1), AMG (T2), Aqua (T3), Supreme (T4)]. Body growth performance, evaluated. There ...

Liver uptake of thyroxine (T4) is mediated by transporters and is rate limiting for hepatic 3,3',5-triiodothyronine (T3) production. We investigated whether hepatic mRNA for T4 transporters is regulated by thyroid state using Xenopus laevis oocytes as an expression system. Because X. laevis oocytes show high endogenous uptake of T4, T4 sulfamate (T4NS) was used as an alternative ligand for the ...

The effects of the Ca2+ channel blockers verapamil, nifedipine, and diltiazem on triiodothyronine (T3) and thyroxine (T4) uptake were tested in cultured cardiomyocytes from 2-day-old rats. Experiments were performed at 37 degrees C in medium with 0.5% BSA for [125I]T3 (100 pM) or 0.1% BSA for [125I]T4 (350 pM). The 15-min uptake of [125I]T3 was 0.124 +/- 0.013 fmol/pM free T3 (n = 6); [125I]T4 ...