Human pathophysiology of high altitude hypoxic brain injury is not well understood and research on the underlying mechanisms is hampered by the lack of well-characterized animal models. In this study, we explored the evolution of brain injury by magnetic resonance imaging (MRI) and histological methods in mice exposed to normobaric hypoxia at 8% oxygen for 48 hours followed by rapid reoxygenati...

INTRODUCTION T2 weighted MR imaging can be helpful in locating epileptogenic lesions since a correlation has been found between the presence of epileptogenic tissue and elevated T2 relaxation time. T2 relaxometry (quantitative assessment of T2 relaxation time) is a sensitive tool for identifying T2 abnormalities. T2 Voxel Based Relaxometry (VBR) is a technique which performs a voxel-level stati...

BACKGROUND AND PURPOSE Intervertebral disk biochemical composition could be accessed in vivo by T1ρ and T2 relaxometry. We found no studies in the literature comparing different segmentation methods for data extraction using these techniques. Our aim was to compare different manual segmentation methods used to extract T1ρ and T2 relaxation times of intervertebral disks from MR imaging. Seven di...

Voxel-based analyses of tissue characteristics such as volume and T2 are usually carried out in isolation. However, as the images are analysed in a common voxel-based framework, it is possible to directly assess the spatial relationships of abnormalities detected by each technique. We utilize this approach in well-characterized patients with unilateral temporal lobe epilepsy (TLE) with hippocam...

We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogenic zone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. T...

The limbic system is presumed to have a central role in cognitive performance, in particular memory. The purpose of this study was to investigate the relationship between limbic white matter microstructure and neuropsychological function in temporal-lobe epilepsy (TLE) patients using diffusion tensor imaging (DTI). Twenty-one adult TLE patients, including 7 non-lesional (nlTLE) and 14 with unil...

The aim of the study was to detect brain oedema with electroconvulsive therapy (ECT). Magnetic resonance imaging (MRI) T(2) relaxation time which is an indicator of brain water was measured one day prior to the first ECT and at two hours after second ECT in five depressive patients prescribed right unilateral (RUL) ECT. MRI T(2), relaxation time was measured in hippocampus (He) and thalamus (Th...

Dramatic physical and physico-chemical changes in soil properties may arise due to temperature and moisture variations as well as swelling of soil organic matter (SOM) under constant conditions. Soil property variations may influence sorption/desorption and transport processes of environmental contaminants and nutrients in natural-organic-matterrich soils. Notwithstanding the studies reported i...

Proton NMR relaxometry is a very powerful tool for investigating porous media and their interaction with water or other liquids and the mobility and interaction of organic molecules in solution. It is commonly used in material science or earth science. However, it is only scarcely applied in soil science although it shows great potential for helping to understand water uptake into the soil matr...

Introduction: Tumor oxygenation plays an important role in malignant progression, metastasis and response to various therapies. F MR oximetry based on the reporter molecule hexafluorobenzene (HFB) using the FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) approach offers quantitative measurements of pO2 with spatial and temporal resolution allowing the dyna...