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background: few investigations have focused on the patients with lupus nephritis (ln) and neuropsychiatric systemic lupus erythematosus (npsle). this study was aimed to investigate the clinical features, mortality, and the predictors for mortality of this group of patients. patients and methods: medical records were retrospectively reviewed in sun yat-sen memorial hospital from 1996 to 2012. da...

background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...

Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by several erythematous papules on the lower back of a 32-year-old man with systemic LE. It is interesting that he didn't di...

The incidence of cardiovascular disease is significantly increased in the two common autoimmune disorders Systemic Lupus Erythematous (SLE) and Rheumatoid Arthritis (RA). Cardiovascular mortality is a major cause of death in these patients. This has been linked to acceleration of the atherosclerotic process in these disorders. Traditional cardiovascular risk factors alone cannot fully explain t...

Segmental renal infarction is a rare situation which has been reported so far in the form of case reports. It's caused usually by cardiac conditions, such as atrial fibrillation, and systemic diseases (e.g. systemic lupus erythematous). We are presenting a case of a 31 year old healthy male, who sustained a left segmental renal infarction, following a motorbike accident. We report his presentat...

objective(s)lupus nephritis (ln) is frequently associated with a poor long-term prognosis. renal biopsy is the diagnostic method of choice in this condition. urine biomarkers have been mentioned in the diagnosis of ln. the study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(umcp-1) as a biomarker of renal involvement in systemic lupus erythematosus.mate...

conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had signif...

Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus. It tends to heal with scarring, hair loss, and pigmentary changes if treatment is not initiated in the early phase of the disease. Classic DLE lesions are initially red-purple macules, papules, or small plaques that rapidly acquire a hyperkeratotic appearance. Only a minority of patients with DLE...