Previous work suggests that innate immunity and representations of tissue can be useful when combined with artificial immune systems. Here we provide a new implementation of tissue for AIS using systemic computation, a new model of computation and corresponding computer architecture based on a systemics world-view and supplemented by the incorporation of natural characteristics. We show using s...

Craniometaphysial dysplasia (CMD) is a rare disorder that mainly affects craniofacial bones. It is caused by mutations within a region of human homolog (Ankh) of the mouse progressive ankylosis (Ank) gene. ANK, together with other factors, regulates intracellular and extracellular levels of pyrophosphate/inorganic phosphate critical for maintaining mineral homeostasis. The systemic manifestatio...

A 4-week-old boy with previous urinary tract infection and documented vesicoureteral reflux presented with urosepsis and septic arthritis of the right hip. Compliance with prophylactic antibiotic therapy had been poor at home. Complications such as bone and joint infection are known to occur after urinary tract infection in children with urologic abnormalities. However, previous similar reports...

Peters' plus syndrome is a rare autosomal recessive condition characterized by a combination of typical ocular defects and other systemic abnormalities. We present a case of this uncommon syndrome that we diagnosed during a fetal ultrasonographical examination. Because the patient exhibited microcephaly and anterior staphyloma of the right eye and because impending rupture was feared, we perfor...

Previous work suggests that innate immunity and representations of tissue can be useful when combined with artificial immune systems. Here we provide a new implementation of tissue for artificial immune systems using systemic computation, a new model of computation and corresponding computer architecture based on a systemics world-view and supplemented by the incorporation of natural characteri...

The levoatriocardinal vein is a very rare but clinically important intrathoracic venous anomaly that connects the systemic (cardinal) and pulmonary venous channels. We report 4 adults with pulmonary-systemic venous communications that can explain the morphology of the extracardiac interatrial shunting through the persistent levoatriocardinal vein. We discuss the imaging features of the 2 types ...

Congenital anomalies affect 1% to 2% of the newborns. The urinary tract and the kidneys are involved in 4-5% of the cases while upper-extremities abnormalities are present in 10%. Certain anomalies occur in isolation, whereas others are associated with systemic conditions. The prenatal detection of fetal anomalies compatible with life is a challenge for both the parents and the physician. The p...

INTRODUCTION Research on associations between medication use during pregnancy and congenital anomalies is significative for assessing the safe use of a medicine in pregnancy. Congenital anomaly (CA) registries do not have optimal information on medicine exposure, in contrast to prescription databases. Linkage of prescription databases to the CA registries is a potentially effective method of ob...

malformation in which intestinal and splenic venous flow bypasses the liver and drains directly into the systemic circulation via a congenital portosystemic shunt. Variable associated anomalies and clinical manifestations caused by the disrupted enterohepatic circulation in CAPV have been reported, including congenital cardiac anomalies, skeletal and visceral anomalies, hepatic neoplasms, liver...

Developmental dental disorders may be due to anomalies in tooth number, size, shape and structure. Gemination and fusion are anomalies of shape with close similarity but with different etiology.Gemination and fusion are anomalies of shape with close similarity but with different etiology.The etiology of germination is not fully understood environmental factors such as trauma, vitamin deficienci...