OBJECTIVE Obesity is a state of chronic inflammation that is associated with insulin resistance and type 2 diabetes mellitus (DM), as well as an increased risk of osteoarthritis (OA). This study was undertaken to define the links between obesity-associated inflammation, insulin resistance, and OA, by testing the hypotheses that 1) tumor necrosis factor (TNF) is critical in mediating these patho...

INTRODUCTION Visfatin is an adipokine that may be involved in intertissular joint communication in osteoarthritis (OA). With a homodimeric conformation, it exerts nicotinamide phosphoribosyltransferase (Nampt) enzymatic activity, essential for nicotinamide adenine dinucleotide biosynthesis. We examined the tissular origin and conformation of visfatin/Nampt in human OA joints and investigated th...

OBJECTIVES Giant cells are commonly present in inflamed synovium, often in close association with the intimal layer. The nature of these multinucleate cells has been reassessed using new cytochemical and immunochemical techniques. METHODS Cryostat sections of non-inflamed, rheumatoid arthritic and osteoarthritic synovia were analysed for the presence of CD68 and non-specific esterase, markers...

In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures, which resemble secondary lymphoid organs. The development of such lymphoid aggregates with germinal centers appears to contribute to the pathogenesis of the disease. Growing evidence indicates that chemokines and their receptors control the rec...

To cite: Aswani Y, Anandpara KM, Hira P, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014208293 DESCRIPTION A 27-year-old man presented with painless swelling of the right knee of 4 months’ duration. There was no history of trauma or other joint involvement. The patient’s serum rheumatoid factor was negative. Radiograph of the knee revealed increased lu...

Total knee arthroplasty is performed routinely for osteoarthritis of the joint. We report a case high-grade diffuse large B-cell lymphoma as an unexpected diagnosis after histopathological examination unusual-looking synovium during total in 68-year-old patient without any systemic symptoms.

PATIENT SERIES I. In 1963-1964, 28 specimens of synovium or joint fluid were studied from patients with RA under treatment in the Rheumatism Foundation Hospital at Heinola. H. In 1966-1967, 33 specimens of joint fluid from patients seen at a Rheumatism Outpatient Clinic in Helsinki were examined. III. In 1967-1968, 27 specimens of synovial fluid and tissue from patients treated at Heinola and i...

An unusual grayish brown discoloration of the synovium was found during a knee arthroscopy of a 72-year-old man. He also had similar pigmentation affecting the skin on the legs, arms, hands, and face. It was found he had been taking 400 mg of amiodarone hydrochloride daily for last 7 years. Amiodarone is known to cause a slate grey pigmentation of skin and cornea, but we believe this is the fir...