The new synergic base [PMDETA.K(TMP)(Et)Zn(Et)] selectively zincates 4-(dimethylamino)pyridine at the 2-position and 4-methoxypyridine at the 3-position, to afford bimetallic potassium pyridylzinc complexes each displaying a novel, but remarkably different, structure.

The mechanical complexity of the hand is indisputable, but there is increasing evidence that its control is simplified in many tasks around synergic groups of muscles that effectively decrease the number of controlled degrees of freedom.

OBJECTIVES MUC7 12-mer (RKSYKCLHKRCR), a cationic peptide derived from human salivary MUC7 mucin, exhibits potent in vitro antifungal activity, as determined by killing assays in phosphate buffer. In this study we examined the MUC7 12-mer antifungal activity alone or in combination with other antifungal agents in LYM medium (modified RPMI 1640). METHODS Antifungal activities of MUC7 12-mer an...

The treatment of animals with non-neoplastic or neoplastic tissue before or after tumor transplantation inhibited the growth of transplanted tumor cells. This phenomenon was most clearly demonstrated when a sub-effective dose of chemotherapeutic agent was administered. In animals bearing a spontaneous tumor, the growth of auto-transplanted tumor was inhibited as compared with that of the same t...

Knowledge of the synergic properties of staphylococcus toxin is comparatively recent: in 1933 Dr. E. L. Burky observed in rabbits immunized with staphylococcus toxin a reaction to the broth in which the toxin had been produced. In explanation he suggested that the "growth activities of the staphylococci had separated from the medium some substance which, when attached to the toxin, became antig...

BACKGROUND Combination therapy is a key strategy for minimizing drug resistance, a common problem in cancer therapy. The microtubule-depolymerizing agent vincristine is widely used in the treatment of acute leukemia. In order to decrease toxicity and chemoresistance of vincristine, this study will investigate the effects of combination vincristine and vorinostat (suberoylanilide hydroxamic acid...

Several group 11 metal complexes with chiral thiourea organocatalysts have been prepared and tested as organocatalysts. The promising results on the influence of metal-assisted thiourea organocatalysts in the asymmetric Friedel-Crafts alkylation of indole with nitrostyrene are described. Better results with the metal complexes have been achieved because of the cooperative effects between the ch...

Angiosarcoma (AS) is a rare neoplasm of endothelial origin that has limited treatment options and poor five-year survival. Using tumorgraft models, we previously showed that AS is sensitive to small-molecule inhibitors that target mitogen-activated/extracellular-signal-regulated protein kinase kinases 1 and 2 (MEK). The objective of this study was to identify drugs that combine with MEK inhibit...