نتایج جستجو برای: synapse
تعداد نتایج: 15136 فیلتر نتایج به سال:
The discovery of the immunological synapse is one of the more striking developments in T cell biology in recent years. The immunological synapse forms at the interface between T cells and antigen-presenting cells (APCs) or target cells. It is characterised by the large-scale segregation of cell surface molecules into concentric zones, forming a bull's eye pattern several microns in diameter (re...
Synapse development requires normal neuronal activities and the precise expression of synapse-related genes. Dysregulation of synaptic genes results in neurological diseases such as autism spectrum disorders (ASD). Mutations in genes encoding chromatin-remodeling factor Brg1/SmarcA4 and its associated proteins are the genetic causes of several developmental diseases with neurological defects an...
Alzheimer’s disease is characterized by the presence of aggregates of amyloid beta (Ab) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse loss correlates most strongly with cognitive decline. Synapse loss occurs prominently around plaques due to accumulations of oligomeric Ab. Recent evidence suggests that tau...
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