Human complement protein C3 was inactivated by using methylamine and thereby generating a SH group from the internal thiol ester. The protein was coupled via this SH group to activated thiol-Sepharose and digested with elastase. Fragment C3d remained attached to the thiol-Sepharose and was subsequently eluted with L-cysteine. Concomitantly, the original SH group was regenerated, and it was then...

Despite reports of the association of hyperparathyroidism and peptic ulcer (Rogers, Keating, Morlock, and Barker, 1947; Black, 1953; Hellstr6m, 1959), the relationship cannot be accepted as proven (Ostrow, Blanshard, and Gray, 1960). The issue is clouded by the differing figures given for the incidence of peptic ulcer in the community (Ivy, Grossman, and Bachrach, 1950; Jones, 1959; Ellison, Ab...

The mathematical model of the movement of the shoreline in a sedimentary ocean basin (A Shoreline Problem) is a Stefan problem with variable latent heat. Swenson et al. [1] utilized an analogy with one-phase melting problem and developed a mathematical model for movement of shoreline in a sedimentary basin in response to changes in sediment line flux, tectonic subsidence of Earth's crust and se...

The excision of the aganglionic segment of the recto-sigmoid colon proposed by Swenson is the logical outcome of the new conception of the aetiology of Hirschsprung's disease and I do not think it necessary to discuss it here any further. The operation which I shall describe constitutes but a technical variance of Swenson's operation and is not a new method; it has also some other applications ...

Whole plant form and function vary spectacularly across the seed plants. In recent years, plant evolutionary ecologists have begun to document this diversity on large geographic scales by analysing ‘functional traits’ that are indicative of whole plant performance across environmental gradients (Swenson & Enquist 2007, Wright et al. 2004). Despite the high degree of functional diversity in trop...

The findings in a consecutive series of 120 children of all ages treated with parenteral fluid therapy in support of major abdominal surgery have been reported (Young, McIntosh, Swain and Levin, 1959). The series included 23 newborn infants with intestinal obstruction. The plan of fluid therapy used was designed to replace initial deficits of water and electrolytes, to provide water, electrolyt...

Bärtsch, Peter, Heimo Mairbäurl, Marco Maggiorini, and Erik R. Swenson. Physiological aspects of high-altitude pulmonary edema. J Appl Physiol 98: 1101–1110, 2005; doi:10.1152/japplphysiol.01167.2004.—High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m. An excessive rise in pulmonary artery pressure (PAP) preceding ed...

One of the regular methods of progression in medicine is by the analysis of large vaguely assorted groups of cases into smaller and exactly defined categories. The process consists in a mixture of observation, abstract reasoning and experiment. As instances of this the work of Hamilton Russell (1922) may be quoted, when by a combination of observation and abstract reasoning he established the e...

This paper is concerned with cases of imperforate anus with recto-urethral fistula in males and some cases with high recto-vaginal fistula in females, all being cases of the type III described by Ladd and Gross (1934) or the high level imperforate anus described by Denis Browne. These cases still present difficult problems (Browne, 1955; Forshall, 1957; Brayton and Norris, 1958; Gross, 1959). D...