Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland. It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine poroepithelioma, dysplastic poroma, malignant syringo acanthoma and porocarcinoma. Treatment with wide local excision but metastatic lesions can...

In order to determine whether the precursor solution of sweat is abnormal in cystic fibrosis, osmolality and concentrations of sodium and chloride were measured in fluid obtained by micropuncture from the sweat gland coil of the nail fold of patients with this disease. Osmolality was 323+/-4.8 SE (mOsm/kg of water), sodium concentration was 151+/-1.1 SE (mEq/liter), and chloride concentration w...

The transforming growth factor-beta superfamily is thought to be involved in the regulation and control of growth and differentiation. These growth factors signal through transmembrane serine/threonine kinase receptors. The activation of type I receptor kinase phosphorylates a family of intracellular signalling proteins called Smads. In the present study, we wanted to localize type I and type I...

Introduction: Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors. Materials and Methods: In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with m...

Nodular hidradenoma is a rare benign tumour of eccrine sweat gland. It usually presents as a solitary, intradermal nodule 0.5 -2 cms in diameter in most instances. It may be red, brown or bluish and sometimes may show superficial ulceration. We are presenting a case report of 50 years old female who presented with painless swelling measuring 3×3 cms over right leg for 2 years. Excisional biopsy...

Secretoglobins is a newly described polypeptide family that has gained a lot of interest in human cancer and inflammation research. Although the first secretoglobin polypeptide was discovered more than 30 years ago, their physiological function is still not known. The aim of this thesis was to study the expression of secretoglobins in normal and neoplastic human cells and tissues, and to clarif...

introduction: natural killer (nk) cells, of which cd56 is a specific marker, play an important role in host defense against tumors. cancer stem cells, of which aldehyde dehydrogenase isoform 1 (aldh1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. we aimed to evaluate the expression of aldh1 and cd56 in common salivary g...