A plasticity-fracture constitutive model is presented for prediction of the behavior of confined plain concrete. A three-parameter yield surface is used to define the elastic limit. Volumetric plastic strain is defined as hardening parameter, which together with a nonlinear plastic potential forms a non-associated flow rule. The use of non-associated flow rule improves the prediction of the dil...

In this paper a constitutive model formulated in the framework of multi-laminate models is applied to analyze pipe-jacking processes. The multi-laminate -based models consider various integration planes to formulate the stress-strain relationship. This basic feature of the framework has the advantage that yield criteria, flow and hardening rules are formulated on planes rather than in three-dim...

Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we show that one of its components, STAT1, negatively regulates the homeostatic component of ocular dominance plasticity in visual cortex. After brief monocular deprivation (...

The plasticity of inhibitory transmission is expected to play a key role in the modulation of neuronal excitability and network function. Over the last two decades, the investigation of the determinants of inhibitory synaptic plasticity has allowed distinguishing presynaptic and postsynaptic mechanisms. While there has been a remarkable progress in the characterization of presynaptically-expres...