Obtaining Heusler alloys at the nanoscale with good crystallographic features is appealing for a large range of technological applications, from biomedical to spintronics devices. In particular, Fe2CrAl as bulk known present magnetic properties that are strongly sensitive chemical and physical constraints, such structural disorder composition. We report throughout structural, morphological, cha...

The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagneti...

Targeted hyperthermia treatment using magnetic nanoparticles is a promising cancer therapy. However, the mechanisms of heat dissipation in the large alternating magnetic field used during such treatment have not been clarified. In this study, we numerically compared the magnetic loss in rotatable nanoparticles in aqueous media with that of non-rotatable nanoparticles anchored to localised struc...

Interface chemistry can be implemented to modulate the aggregation and dispersion of nanoparticles in a colloidal solution. In this experimental study, we demonstrate the controlled aggregation of superparamagnetic magnetite nanoparticles in organic and aqueous solutions. With decrease in solution pH, individual nanoparticles (12-14 nm) reproducibly cluster to form ~52 nm monodisperse aggregate...

We report a simple phase transfer based synthesis route for two novel anisotropic water soluble iron oxide nanoparticle shapes, namely, nanoplates and nanoflowers. The nanoplates and nanoflowers are initially prepared in an organic solvent via a modified ‘‘heat-up’’ method. Then, the crystalline nanoparticles are rendered hydrophilic via sonication in the presence of dextran and water. These na...

High-temperature synthesized monodisperse superparamagnetic iron oxide nanoparticles are obtained with a strongly bound ligand shell of oleic acid and its decomposition products. Most applications require a stable presentation of a defined surface chemistry; therefore, the native shell has to be completely exchanged for dispersants with irreversible affinity to the nanoparticle surface. We eval...

The suitability of magnetic nanoparticles (MNPs) to act as heat nano-sources by application of an alternating magnetic field has recently been studied due to their promising applications in biomedicine. The understanding of the magnetic relaxation mechanism in biocompatible nanoparticle systems is crucial in order to optimize the magnetic properties and maximize the specific absorption rate (SA...

We report a novel purification system for 6 His-tagged proteins by magnetic affinity separation. We have developed superparamagnetic Fe3O4@SiO core-shell particles with immobilized surface iminodiacetate groups to chelate with Ni. This Ni magnetic silica nanoparticle has been shown as an efficient carrier, binder and anchor to obtain his-tagged protein directly from total cell lysate. The struc...

A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic γFe(2)O(3) nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate f...

Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential bi...