The dissolution property of the poorly water-soluble drug, flurbiprofen (FP) was improved by a novel supercritical freeze granulation using supercritical carbon dioxide. Supercritical freeze granulation was defined as a production method of the granulated substances by using the dry ice to generate intentionally for the rapid atomization of the supercritical carbon dioxide to the atmospheric pr...

This study investigates the differences between the predictions of various properties of rigid and flexible simple point charge water models at supercritical conditions. Molecular dynamics simulations were conducted for supercritical water in a temperature range of 773-1073 K and densities in the range 115-659 kg/m3. We present thermodynamic data, pair correlation functions, selfdiffusivity, po...

Trichlorocarbanilide has widely been used in cosmetics and household products, but the extremely low solubility of trichlorocarbanilide in water constrains the development of water-based products. In order to enhance the bioavailability, trichlorocarbanilide were micronized using supercritical fluid. Supercritical carbon dioxide was selected due to relatively low critical temperature and the ra...

Water is not restricted to moderate temperatures and low pressures, but can exist up to very high temperatures, far above its critical point at 647 K. In this supercritical regime, water can be gradually compressed from gas-like to liquid-like densities. The resulting dense supercritical states have extraordinary properties which can be tuned by temperature and pressure, and form the basis for ...

The conversion of biomass to a lowor medium-heating-value gaseous fuel (biomass gasification) generally involves two processes. The first process, pyrolysis, releases the volatile components of the fuel at temperatures below 600°C (1,112°F) via a set of complex reactions. Included in these volatile vapors are hydrocarbon gases, hydrogen, carbon monoxide, carbon dioxide, tars, and water vapor. B...