A simple, rapid and accurate liquid chromatography - tandem mass spectrometry method was developed and validated for the quantification of acetazolamide in beagle plasma using sulfadiazine as the internal standard. After extraction by acetonitrile, the analytes were separated by a rapid gradient elution with acetonitrile and water as the mobile phase on a SHIMADZU VP-ODS C18 column and then det...

Historically, military recruits have been at high risk of acquiring meningococcal disease. Beginning in the 1940s, the US military relied on mass treatment with sulfadiazine to control outbreaks in training camps. In the 1960s, a vaccine was developed in response to the emergence of sulfadiazine-resistant strains. Since 1971, all new recruits in the US military have been immunized against Neiss...

IntroductionAIDS patients are more susceptible to opportunistic diseases, such as toxoplasma encephalitis, because of weakened immune systems. Toxoplasma encephalitis manifests a severe neurological crisis in HIV patients. The standard initial treatments sulfadiazine and pyrimethamine. This case presents an patient treated with alternative regimen for encephalitis.Case descriptionA young Acehne...

silver sulfadiazine is used to prevent and treat infections of second- and third-degree burns. it kills a wide variety of bacteria. in this study silver sulfadiazine was used in gelatin based electro-spun nano-fibers with various drug to polymer ratios (0, 5, 10, 15 and 20 %). sem, edx and ftir analysis showed that the continuous, bead-free, fine fibers containing silver sulfadiazine as an anti...

Toxoplasma gondii is deemed a successful parasite worldwide with wide range of hosts. Currently, combination pyrimethamine and sulfadiazine serves as the first-line treatment; however, these drugs have serious adverse effects. Therefore, it imperative to focus on new therapies that produce desired effect lowest possible dose. The designation synthesis sulfonamide-1,2,3-triazole hybrids (3a–c) w...

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal adverse drug reaction associated with skin rash, fever, eosinophilia, and multiple organ injury. A number of pharmacological agents are known to cause DRESS syndrome such as allopurinol, anticonvulsants, vancomycin, trimethoprime-sulfamethoxazole, and pyrimethamine-sulfadiazine. Here, we descr...

The presence of antibiotic sulfadiazine (SFD) poses threats to the ecosystem and human health, traditional wastewater treatment processes are not ideal for removal. Therefore, it is urgent develop with high efficiency targeting sulfadiazine. This study investigated degradation mineralization mechanisms SFD by ozone-based catalysis including ozone/persulfate (PS) ozone/peroxymonosulfate (PMS). d...