According to a recent report from the Office of Suicide Prevention in the US Department of Veterans Affairs, veterans represent 8.5% of the US population, but account for 18% of all deaths from suicide. The aim of this study of psychiatric patients (n=39; 87% male) was to compare blood gene expression data from veterans with a history of one or more suicide attempts to veterans who had never at...

Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation and elongation of shorter-chain precursor fatty acids linoleic acid (LA, 18:2n-6) and α-linolenic acid (ALA, 18:3n-3). We compared DNA methylation patterns in genes invo...

Targeted mutagenesis is one of the major tools for determining the function of a given gene and its involvement in bacterial pathogenesis. In mycobacteria, gene deletion is often accomplished by using allelic exchange techniques that commonly utilise a suicide delivery vector. We have adapted a widely-used suicide delivery vector (p1NIL) for cloning two flanking regions of a gene using ligation...

background: suicide is one of the most important health problems in communities and knowledge of rates and epidemiology of it in any region could help in control and preventing programs .longitudinal registration of annual death data has been employed in this study. methods: in an analytical and cross sectional study pre conducted forms of suicide was engaged to register data , crude and specif...

background elimination of suicide attempts is impossible, but they can be reduced dramatically by an organized planning. the present study aimed to survey the suicide trends in fars province (iran), during 2004-2009 to better understand the prevalence and status of suicide.   methods this survey was a cross-sectional study. the demographic data were collected from the civil status registry betw...

In gene therapy, effective and selective suicide gene expression is crucial. We exploited the endogenous Long INterspersed Element-1 (L1) machinery often reactivated in human cancers to integrate the Herpes Simplex Virus Thymidine Kinase (HSV-TK) suicide gene selectively into the genome of cancer cells. We developed a plasmid-based system directing HSV-TK expression only when reverse transcribe...

objective: in an attempt to develop safer and more effective gene therapy approaches as a realistic treatment for various forms of cancer, researchers are increasingly using tumor-specific promoters (tsp) to drive the expression of the gene of interest and eradicate cancer cells. in this study, for the first time we introduce the oct-4 promoter as a cancer-specific promoter with a high efficacy...

abstract aims: the reason of selecting self-immolation as a mean to commit suicide is unclear. this study was designed to compare 2 groups of people with and without intention to suicide that had self-immolated. instrument & methods: all 227 self-immolated patients who had been admitted to the burn unit of imam khomeini hospital of kermanshah city, iran, during 2003 to 2004  participated in thi...

ôbjective: presently, the issue of attempted suicide now poses one of the major challenges facing the health-care providers in ïran and other countries. âlthough in previous years, the number of people entering to hospital emergency departments after deliberately taking overdoses or injuring themselves has been steadily increased in ïran, however, there is less attention to the issue of suicide...

To enhance the efficacy of ganciclovir/herpes simplex virus thymidine kinase (GCV/HSV-TK) suicide gene therapy for nasopharyngeal cancer KB, we developed long-circulating liposome-encapsulated GCV, and evaluated cytotoxicity in vitro and in vivo. PEGylated liposome-encapsulated GCV (PEG-GCV-lipo) was prepared by the freeze-thawing method. In vitro experiments demonstrated that GCV from liposome...