In customary, frequent itemsets are propogated from large data sets by employing association rule mining algorithms like Apriori, Partition, Pincer-Search, Incremental and Border algorithm etc., which gains inordinately longer computer time to cast up all the frequent itemsets. On utilizing Genetic Algorithm (GA) the scheme is reformed.. The outstanding benefit of utilizing GA in determining th...

Pediatric communication directly contributes to treatment adherence, fewer symptoms, better clinical responses, healthier treatment adaptation and management of psychosocial issues. This study aimed to evaluate associations between the clinical and sociodemographic data of caregivers and children and the communicative patterns of pediatricians. Three oncohematology physicians and 44 child-careg...

The grave inadequacy of current international attempts to curtail organ trafficking signals the need for a new approach in the form of a fundamental paradigm shift. Instead of continuing to focus efforts solely on criminalization, countries must devise a broad scheme aimed at decreasing organ shortages. These shortages fuel the illegal organ market, as people desperate for life-saving transplan...

Myocardial aging is a constellation of concurrent processes occurring at organ, cellular, and molecular levels. Despite this complexity, differences become readily identifiable by comparing phenotypic characteristics of mammalian cardiomyocytes and cardiac stem cells in young versus old hearts. One hallmark unique to the early postnatal myocardium is increased cellular proliferation, resulting ...

Thyroid storm represents the extreme manifestation of thyrotoxicosis as a true endocrine emergency. Although Grave's disease is the most common underlying disorder in thyroid storm, there is usually a precipitating event or condition that transform the patient into life-threatening thyrotoxicosis. Treatment of thyroid storm involves decreasing new hormone synthesis, inhibiting the release of th...

* This study has been supported by a grant from the office of the Surgeon General, Medical Research and Development, U.S. Army. † Howard Hughs Foundation investigator. WE have reported that spontaneous attacks of periodic paralysis are preceded by large increases of urinary aldosterone and by intense retention of sodium (Conn et al. 1956). This is followed shortly by sequestration of pot...

PURPOSE OF REVIEW Interferon therapy can induce or exacerbate sarcoidosis. With the increasing use of interferons it is highly likely that more cases of sarcoidosis will be encountered by clinicians. We describe three unusual cases of interferon-induced sarcoidosis and review the most recent relevant literature on this subject. RECENT FINDINGS Interferons, on account of their antiviral antigr...

How cell proliferation subsides as cells terminally differentiate remains largely enigmatic, although this phenomenon is central to the existence of multicellular organisms. Here, we show that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2. This interaction requires a LXCXE motif that is evolutionary conserved among ...

BURNELL, JAMES M., ELIZABETH J. TEUBNER, AND DAVID P. SIMPSON. bfetabolic acidosis accompanying potasszum deprivation. Am. J. Physiol. 227(2): 329-333. 1974.-Removal of potassium, with or without substitution of an equivalent amount of sodium, from the diet of dogs causes a prompt and persistent decrease in distal H+ secretion resulting in an increase in urine pH. The sequelae to this change in...

Endotoxin induces many profound vascular effects, including venous pooling, changes in resistance to blood flow in many organs, and circulatory collapse leading to death. Prominent among the early vascular effects of endotoxin is the rapid development of hepatic and intestinal congestion (2-4). One apparent mechanism of splanchnic blood pooling in endotoxin shock is hepatic venoconstriction. Li...