نتایج جستجو برای: subinhibitory concentrations

تعداد نتایج: 306940  

Journal: :Antimicrobial agents and chemotherapy 2015
Sheng-Hui Tsai Hsin-Chih Lai Shiau-Ting Hu

Subinhibitory doses of antibiotics have been shown to cause changes in bacterial morphology, adherence ability, and resistance to antibiotics. In this study, the effects of subinhibitory doses of aminoglycoside antibiotics on Mycobacterium abscessus were investigated. The treatment of M. abscessus cells with subinhibitory doses of amikacin was found to change their colony from a smooth to a rou...

Journal: :Antimicrobial agents and chemotherapy 2013
P Matzneller S Krasniqi M Kinzig F Sörgel S Hüttner E Lackner M Müller M Zeitlinger

Although azithromycin is extensively used in the treatment of respiratory tract infections as well as skin and skin-related infections, pharmacokinetics of azithromycin in extracellular space fluid of soft tissues, i.e., one of its therapeutic target sites, are not yet fully elucidated. In this study, azithromycin concentration-time profiles in extracellular space of muscle and subcutaneous adi...

Journal: :The Journal of antimicrobial chemotherapy 2008
D M O'Sullivan J Hinds P D Butcher S H Gillespie T D McHugh

OBJECTIVES To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis. METHODS Genome-wide expression profiling followed by quantitative RT (qRT)-PCR was used to study the effect of ciprofloxacin on M. tuberculosis gene expression. RESULTS Microarray analysis showed that 16/110 genes involved...

Journal: :The Journal of antimicrobial chemotherapy 2001
K Nagai T A Davies B E Dewasse M R Jacobs P C Appelbaum

The ability of sequential subcultures in subinhibitory concentrations of gemifloxacin, trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin to select resistant mutants was studied in 16 pneumococci [eight with ciprofloxacin MICs (mg/L) 0.25-1; four with 8-16; four with 16-32]. Subculturing was done 50 times, or until mutants with elevated MICs (> or = 4 x) to the selecting drug emerged. ...

Journal: :Antimicrobial agents and chemotherapy 1998
K Ohlsen W Ziebuhr K P Koller W Hell T A Wichelhaus J Hacker

Concentrations of antibiotics below the MIC are able to modulate the expression of virulence-associated genes. In this study, the influence of subinhibitory doses of 31 antibiotics on the expression of the gene encoding the staphylococcal alpha-toxin (hla), a major virulence factor of Staphylococcus aureus, was investigated with a novel gene fusion protocol. The most striking observation was a ...

2013
Mrudula Patel Roxanne Naidoo Foluso John Owotade

Aim. This study investigated the effect of Dodonaea viscosa var. angustifolia (DVA) on the virulence properties of cariogenic Streptococcus mutans and Porphyromonas gingivalis implicated in periodontal diseases. Methods. S. mutans was cultured in tryptone broth containing a crude leaf extract of DVA for 16 hours, and the pH was measured after 10, 12, 14, and 16 h. Biofilms of S. mutans were gro...

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