In the investigation of malabsorption syndromes and folic acid deficiency, the folic acid absorption test may be used to determine the degree of absorption of folic acid from the intestine and also to measure the rate of clearance from the serum . The test is based on loading the patient with subcutaneous folic acid followed by an oral dose of this vitamin. Samples of blood are withdrawn at sui...

OBJECTIVE Periconceptional use of folic acid may effectively reduce the risk of fetal neural tube defects. The objective of the present study was to evaluate the awareness and use of folic acid during periconceptional period in Taiwan. MATERIALS AND METHODS A cross-sectional study was performed at Taiwan Adventist Hospital between March 2008 and December 2008. Data were obtained using a quest...

Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia; more recently the theoretical potential for high-dose folic acid to promote cancer has been highlighted. In this paper we set out to examine the appearance of unmetabolised folic acid both in cord b...

BACKGROUND Studies in the 1990s have found that periconceptional dietary folate, supplementation of folic acid or supplemental multivitamins containing folic acid, help prevent neural tube defect (NTDs) if taken at the right time. This literature review assesses the extant folic acid public health campaigns literature and identifies some common variables used in folic acid consumption campaign ...

BACKGROUND A decrease in folic acid and subsequent DNA hypomethylation may be involved in gastric carcinogenesis. Epidemiological and nutritional studies have indicated that folate status modulates the risk of developing cancers. AIMS To investigate whether folic acid plays an important role in the chemoprevention of gastric carcinogenesis induced by N-ethyl-N-nitrosoguanidine (ENNG) in beagl...

Several observations in Go have suggested that folic acid may have a role in the oxidation of tyrosine, although no specific function of the vitamin in the metabolism of this ammo acid has been established. Woodruff and Darby (1) and Woodruff et al. (2) found that tyrosyluria, the excretion of p-hydroxyphenyl metabolites of tyrosine, could be corrected in scorbutic guinea pigs, not only by asco...

background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...

background: pregnancy associated osteoporosis (pao) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. soluble receptor activator of nuclear factor-kappa b ligand (srankl) to osteoprotegerin (opg) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteopor...

background: several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. this study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in northern iran.   methods : in this hospital based study from march 2006 to september 2009, we screened the total number of live births at all hospitals in golestan provi...